Cross resistance to brevetoxin-3 by kdr and super-kdr mutations in house flies

The dinoflagellate Karenia brevis is a causative agent of red tides in the Gulf of Mexico and generates a potent family of structurally related brevetoxins that act via the voltage-sensitive Na+ channel. This project was undertaken to better understand the neurotoxicology and kdr cross-resistance to...

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Veröffentlicht in:	Pesticide biochemistry and physiology 2024-05, Vol.201, p.105898-105898, Article 105898
Hauptverfasser:	Swale, Daniel R., Bloomquist, Jeffrey R., McComic, Sarah E., Burgess, Edwin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	algal blooms Animals Brevetoxin-3 brevetoxins central nervous system cross resistance Dinoflagellida - drug effects Dinoflagellida - genetics etiological agents Gulf of Mexico hemocoel Houseflies - drug effects Houseflies - genetics Karenia brevis Larva - drug effects Larva - genetics larvae Marine Toxins mechanism of action Musca domestica mutants Mutation neurophysiology Oxocins - pharmacology paralysis pesticides Polyether Toxins pyrethrins Pyrethroid resistance sodium channels toxicity
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