Transcriptomics-based analysis reveals the nephrotoxic effects of triphenyltin (TPT) on SD rats by affecting RAS, AQPs and lipid metabolism

Triphenyltin (TPT) is a class of organotin compounds that are extensively used in industry and agriculture. They have endocrine-disrupting effects and cause severe environmental contamination. Pollutants may accumulate in the kidneys and cause pathological complications. However, the mechanism of TP...

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Veröffentlicht in:	Pesticide biochemistry and physiology 2024-02, Vol.199, p.105792-105792, Article 105792
Hauptverfasser:	Qian, Mingqing, Ren, Xijuan, Mao, Penghui, Li, Zhi, Qian, Tingting, Wang, Li, Liu, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	AQPs blood serum gene expression immunohistochemistry industry Kidney injury kidneys lipid metabolism lipids males mechanism of action nephrotoxicity peroxisome proliferator-activated receptors pesticides pollution PPAR protein synthesis RAS rats renin-angiotensin system sequence analysis TPT transcriptome Transcriptome analysis transcriptomics
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