Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy
Background Diabetic nephropathy (DN), which is a chronic outcome of diabetes mellitus (DM), usually progresses to end-stage renal disease (ESRD). The DN pathophysiology, nevertheless, is not well-defined. Several miRNAs were reported to be either risk or protective factors in DN. Methods, and result...
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| Veröffentlicht in: | Molecular biology reports 2023-12, Vol.50 (12), p.9793-9803 |
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| description | Background
Diabetic nephropathy (DN), which is a chronic outcome of diabetes mellitus (DM), usually progresses to end-stage renal disease (ESRD). The DN pathophysiology, nevertheless, is not well-defined. Several miRNAs were reported to be either risk or protective factors in DN.
Methods, and results
The present study sought to inspect the potential diagnostic and prognostic value of
hsa-miR-221
in DN. The study included 200 participants divided into four groups: Group 1 (50 patients with DN), Group 2 (50 diabetic patients without nephropathy), Group 3 (50 nondiabetic patients with CKD), and Group 4 (50 healthy subjects as a control group). Patients in groups 1 and 3 were further classified based on the presence of macroalbuminuria and microalbuminuria.
Hsa-miR-221
expression was measured by RT- qRT-PCR. DN patients had significantly elevated serum
hsa-miR-221
levels than the other groups, while diabetic patients without nephropathy exhibited elevated levels compared to both nondiabetic patients with CKD, and the control group. The DN patients with macroalbuminuria revealed significantly higher mean values of
hsa-miR-221
relative to the patients with microalbuminuria. Significant positive associations were observed in the DN group between serum
hsa-miR-221
and fasting insulin, fasting glucose, HOMA IR, ACR, and BMI. The ROC curve analysis of serum
hsa-miR-221
in the initial diagnosis of DN in DM revealed high specificity and sensitivity.
Conclusions
It is concluded that
hsa-miR-221
has the potential to be a useful biomarker for prognostic and diagnostic purposes in DN. |
| doi_str_mv | 10.1007/s11033-023-08846-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153546912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2877389573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-e7a8e6316ad9753fb6863520dc041d9405257f4265d7cc25ab1ba6ae2554b8033</originalsourceid><addsrcrecordid>eNqFkUtLxDAUhYMoOj7-gAspuHETTXLz6lIGXyAIouuQtulMxk5bk3Yx_96MMyq40EUISb577s05CJ1SckkJUVeRUgKACUtLay7xagdNqFCAea70LpoQIBRzLegBOoxxQQjhVIl9dABKAwUuJ8hOfSjHxg6-nWXzaPHSP2PGaGZjZrO-i9EXjcsqb2dtFwdfZratsj50X8fCd0sb3lzIunqNFW5927p-HrreDvPVMdqrbRPdyXY_Qq-3Ny_Te_z4dPcwvX7EJScwYKesdhKotFWuBNSF1BIEI1WZhq5yTgQTquZMikqVJRO2oIWV1jEheKGTD0foYqObhnsfXRzM0sfSNY1tXTdGA1SA4DKn7F-UaaVA58nJhJ7_QhfdGNr0kUTlwBXQXCaKbagyJMeCq00ffLJlZSgx66zMJiuTsjKfWZlVKjrbSo_F0lXfJV_hJAA2QExP7cyFn95_yH4Ad5GeGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2893473196</pqid></control><display><type>article</type><title>Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Abdel-Tawab, Marwa Sayed ; Mohamed, Mohamed Gamal ; Doudar, Noha A. ; Rateb, Enas Ezzat ; Reyad, Hoda Ramadan ; Elazeem, Naglaa Adli Abd</creator><creatorcontrib>Abdel-Tawab, Marwa Sayed ; Mohamed, Mohamed Gamal ; Doudar, Noha A. ; Rateb, Enas Ezzat ; Reyad, Hoda Ramadan ; Elazeem, Naglaa Adli Abd</creatorcontrib><description>Background
Diabetic nephropathy (DN), which is a chronic outcome of diabetes mellitus (DM), usually progresses to end-stage renal disease (ESRD). The DN pathophysiology, nevertheless, is not well-defined. Several miRNAs were reported to be either risk or protective factors in DN.
Methods, and results
The present study sought to inspect the potential diagnostic and prognostic value of
hsa-miR-221
in DN. The study included 200 participants divided into four groups: Group 1 (50 patients with DN), Group 2 (50 diabetic patients without nephropathy), Group 3 (50 nondiabetic patients with CKD), and Group 4 (50 healthy subjects as a control group). Patients in groups 1 and 3 were further classified based on the presence of macroalbuminuria and microalbuminuria.
Hsa-miR-221
expression was measured by RT- qRT-PCR. DN patients had significantly elevated serum
hsa-miR-221
levels than the other groups, while diabetic patients without nephropathy exhibited elevated levels compared to both nondiabetic patients with CKD, and the control group. The DN patients with macroalbuminuria revealed significantly higher mean values of
hsa-miR-221
relative to the patients with microalbuminuria. Significant positive associations were observed in the DN group between serum
hsa-miR-221
and fasting insulin, fasting glucose, HOMA IR, ACR, and BMI. The ROC curve analysis of serum
hsa-miR-221
in the initial diagnosis of DN in DM revealed high specificity and sensitivity.
Conclusions
It is concluded that
hsa-miR-221
has the potential to be a useful biomarker for prognostic and diagnostic purposes in DN.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-023-08846-y</identifier><identifier>PMID: 37831346</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>albuminuria ; Albuminuria - diagnosis ; Animal Anatomy ; Animal Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; blood serum ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Nephropathies - diagnosis ; Diabetic Nephropathies - genetics ; Diabetic nephropathy ; End-stage renal disease ; Fasting ; glucose ; Histology ; Humans ; insulin ; Kidney diseases ; Life Sciences ; microRNA ; MicroRNAs - genetics ; Morphology ; Nephropathy ; Original Article ; pathophysiology ; Prognosis ; Renal Insufficiency, Chronic ; risk</subject><ispartof>Molecular biology reports, 2023-12, Vol.50 (12), p.9793-9803</ispartof><rights>The Author(s) 2023. corrected publication 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c403t-e7a8e6316ad9753fb6863520dc041d9405257f4265d7cc25ab1ba6ae2554b8033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-023-08846-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-023-08846-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37831346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Tawab, Marwa Sayed</creatorcontrib><creatorcontrib>Mohamed, Mohamed Gamal</creatorcontrib><creatorcontrib>Doudar, Noha A.</creatorcontrib><creatorcontrib>Rateb, Enas Ezzat</creatorcontrib><creatorcontrib>Reyad, Hoda Ramadan</creatorcontrib><creatorcontrib>Elazeem, Naglaa Adli Abd</creatorcontrib><title>Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Background
Diabetic nephropathy (DN), which is a chronic outcome of diabetes mellitus (DM), usually progresses to end-stage renal disease (ESRD). The DN pathophysiology, nevertheless, is not well-defined. Several miRNAs were reported to be either risk or protective factors in DN.
Methods, and results
The present study sought to inspect the potential diagnostic and prognostic value of
hsa-miR-221
in DN. The study included 200 participants divided into four groups: Group 1 (50 patients with DN), Group 2 (50 diabetic patients without nephropathy), Group 3 (50 nondiabetic patients with CKD), and Group 4 (50 healthy subjects as a control group). Patients in groups 1 and 3 were further classified based on the presence of macroalbuminuria and microalbuminuria.
Hsa-miR-221
expression was measured by RT- qRT-PCR. DN patients had significantly elevated serum
hsa-miR-221
levels than the other groups, while diabetic patients without nephropathy exhibited elevated levels compared to both nondiabetic patients with CKD, and the control group. The DN patients with macroalbuminuria revealed significantly higher mean values of
hsa-miR-221
relative to the patients with microalbuminuria. Significant positive associations were observed in the DN group between serum
hsa-miR-221
and fasting insulin, fasting glucose, HOMA IR, ACR, and BMI. The ROC curve analysis of serum
hsa-miR-221
in the initial diagnosis of DN in DM revealed high specificity and sensitivity.
Conclusions
It is concluded that
hsa-miR-221
has the potential to be a useful biomarker for prognostic and diagnostic purposes in DN.</description><subject>albuminuria</subject><subject>Albuminuria - diagnosis</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>blood serum</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic nephropathy</subject><subject>End-stage renal disease</subject><subject>Fasting</subject><subject>glucose</subject><subject>Histology</subject><subject>Humans</subject><subject>insulin</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>Morphology</subject><subject>Nephropathy</subject><subject>Original Article</subject><subject>pathophysiology</subject><subject>Prognosis</subject><subject>Renal Insufficiency, Chronic</subject><subject>risk</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLxDAUhYMoOj7-gAspuHETTXLz6lIGXyAIouuQtulMxk5bk3Yx_96MMyq40EUISb577s05CJ1SckkJUVeRUgKACUtLay7xagdNqFCAea70LpoQIBRzLegBOoxxQQjhVIl9dABKAwUuJ8hOfSjHxg6-nWXzaPHSP2PGaGZjZrO-i9EXjcsqb2dtFwdfZratsj50X8fCd0sb3lzIunqNFW5927p-HrreDvPVMdqrbRPdyXY_Qq-3Ny_Te_z4dPcwvX7EJScwYKesdhKotFWuBNSF1BIEI1WZhq5yTgQTquZMikqVJRO2oIWV1jEheKGTD0foYqObhnsfXRzM0sfSNY1tXTdGA1SA4DKn7F-UaaVA58nJhJ7_QhfdGNr0kUTlwBXQXCaKbagyJMeCq00ffLJlZSgx66zMJiuTsjKfWZlVKjrbSo_F0lXfJV_hJAA2QExP7cyFn95_yH4Ad5GeGA</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Abdel-Tawab, Marwa Sayed</creator><creator>Mohamed, Mohamed Gamal</creator><creator>Doudar, Noha A.</creator><creator>Rateb, Enas Ezzat</creator><creator>Reyad, Hoda Ramadan</creator><creator>Elazeem, Naglaa Adli Abd</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20231201</creationdate><title>Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy</title><author>Abdel-Tawab, Marwa Sayed ; Mohamed, Mohamed Gamal ; Doudar, Noha A. ; Rateb, Enas Ezzat ; Reyad, Hoda Ramadan ; Elazeem, Naglaa Adli Abd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-e7a8e6316ad9753fb6863520dc041d9405257f4265d7cc25ab1ba6ae2554b8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>albuminuria</topic><topic>Albuminuria - diagnosis</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>blood serum</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Nephropathies - diagnosis</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic nephropathy</topic><topic>End-stage renal disease</topic><topic>Fasting</topic><topic>glucose</topic><topic>Histology</topic><topic>Humans</topic><topic>insulin</topic><topic>Kidney diseases</topic><topic>Life Sciences</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>Morphology</topic><topic>Nephropathy</topic><topic>Original Article</topic><topic>pathophysiology</topic><topic>Prognosis</topic><topic>Renal Insufficiency, Chronic</topic><topic>risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Tawab, Marwa Sayed</creatorcontrib><creatorcontrib>Mohamed, Mohamed Gamal</creatorcontrib><creatorcontrib>Doudar, Noha A.</creatorcontrib><creatorcontrib>Rateb, Enas Ezzat</creatorcontrib><creatorcontrib>Reyad, Hoda Ramadan</creatorcontrib><creatorcontrib>Elazeem, Naglaa Adli Abd</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Tawab, Marwa Sayed</au><au>Mohamed, Mohamed Gamal</au><au>Doudar, Noha A.</au><au>Rateb, Enas Ezzat</au><au>Reyad, Hoda Ramadan</au><au>Elazeem, Naglaa Adli Abd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>50</volume><issue>12</issue><spage>9793</spage><epage>9803</epage><pages>9793-9803</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Background
Diabetic nephropathy (DN), which is a chronic outcome of diabetes mellitus (DM), usually progresses to end-stage renal disease (ESRD). The DN pathophysiology, nevertheless, is not well-defined. Several miRNAs were reported to be either risk or protective factors in DN.
Methods, and results
The present study sought to inspect the potential diagnostic and prognostic value of
hsa-miR-221
in DN. The study included 200 participants divided into four groups: Group 1 (50 patients with DN), Group 2 (50 diabetic patients without nephropathy), Group 3 (50 nondiabetic patients with CKD), and Group 4 (50 healthy subjects as a control group). Patients in groups 1 and 3 were further classified based on the presence of macroalbuminuria and microalbuminuria.
Hsa-miR-221
expression was measured by RT- qRT-PCR. DN patients had significantly elevated serum
hsa-miR-221
levels than the other groups, while diabetic patients without nephropathy exhibited elevated levels compared to both nondiabetic patients with CKD, and the control group. The DN patients with macroalbuminuria revealed significantly higher mean values of
hsa-miR-221
relative to the patients with microalbuminuria. Significant positive associations were observed in the DN group between serum
hsa-miR-221
and fasting insulin, fasting glucose, HOMA IR, ACR, and BMI. The ROC curve analysis of serum
hsa-miR-221
in the initial diagnosis of DN in DM revealed high specificity and sensitivity.
Conclusions
It is concluded that
hsa-miR-221
has the potential to be a useful biomarker for prognostic and diagnostic purposes in DN.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>37831346</pmid><doi>10.1007/s11033-023-08846-y</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | albuminuria Albuminuria - diagnosis Animal Anatomy Animal Biochemistry Biomarkers Biomedical and Life Sciences blood serum Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - genetics Diabetic Nephropathies - diagnosis Diabetic Nephropathies - genetics Diabetic nephropathy End-stage renal disease Fasting glucose Histology Humans insulin Kidney diseases Life Sciences microRNA MicroRNAs - genetics Morphology Nephropathy Original Article pathophysiology Prognosis Renal Insufficiency, Chronic risk |
| title | Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy |
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