Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis
There is a growing interest in phages as potential biotechnological tools in human health owing to the antibacterial activity of these viruses. In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species Phietavirus Henu 2 . PhiV_005_BRA/2016 was d...
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| Veröffentlicht in: | Virus genes 2023-06, Vol.59 (3), p.464-472 |
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| creator | do Socorro Fôro Ramos, Endrya Bahia, Santana Lobato de Oliveira Ribeiro, Geovani Villanova, Fabiola de Pádua Milagres, Flávio Augusto Brustulin, Rafael Pandey, Ramendra Pati Deng, Xutao Delwart, Eric da Costa, Antonio Charlys Leal, Élcio |
| description | There is a growing interest in phages as potential biotechnological tools in human health owing to the antibacterial activity of these viruses. In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species
Phietavirus Henu 2
. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus
Phietavirus
, species of
Phietavirus Henu 2
. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant
Staphylococcus aureus
(MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial. |
| doi_str_mv | 10.1007/s11262-023-01990-4 |
| format | Article |
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Phietavirus Henu 2
. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus
Phietavirus
, species of
Phietavirus Henu 2
. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant
Staphylococcus aureus
(MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial.</description><identifier>ISSN: 0920-8569</identifier><identifier>EISSN: 1572-994X</identifier><identifier>DOI: 10.1007/s11262-023-01990-4</identifier><identifier>PMID: 37004601</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antibacterial activity ; antibacterial properties ; Antibiotics ; Bacteria ; Bacterial infections ; Bacteriophages ; Biomedical and Life Sciences ; Biomedicine ; DNA ; Drug resistance ; Gastroenteritis ; genome ; Genomes ; Genomics ; human health ; Humans ; Laboratories ; lifestyle ; Medical Microbiology ; Metagenomics ; Methicillin ; Methicillin-Resistant Staphylococcus aureus ; Multidrug resistance ; multiple drug resistance ; Original Paper ; Phages ; Phietavirus ; Plant Sciences ; prediction ; Public health ; Siphoviridae ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus infections ; Virology ; Virome ; Viruses</subject><ispartof>Virus genes, 2023-06, Vol.59 (3), p.464-472</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-e520a776e869dc0cbb386143cb5fa08325322c8675e90bc5db074c3250919e573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11262-023-01990-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11262-023-01990-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37004601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>do Socorro Fôro Ramos, Endrya</creatorcontrib><creatorcontrib>Bahia, Santana Lobato</creatorcontrib><creatorcontrib>de Oliveira Ribeiro, Geovani</creatorcontrib><creatorcontrib>Villanova, Fabiola</creatorcontrib><creatorcontrib>de Pádua Milagres, Flávio Augusto</creatorcontrib><creatorcontrib>Brustulin, Rafael</creatorcontrib><creatorcontrib>Pandey, Ramendra Pati</creatorcontrib><creatorcontrib>Deng, Xutao</creatorcontrib><creatorcontrib>Delwart, Eric</creatorcontrib><creatorcontrib>da Costa, Antonio Charlys</creatorcontrib><creatorcontrib>Leal, Élcio</creatorcontrib><title>Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis</title><title>Virus genes</title><addtitle>Virus Genes</addtitle><addtitle>Virus Genes</addtitle><description>There is a growing interest in phages as potential biotechnological tools in human health owing to the antibacterial activity of these viruses. In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species
Phietavirus Henu 2
. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus
Phietavirus
, species of
Phietavirus Henu 2
. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant
Staphylococcus aureus
(MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial.</description><subject>Antibacterial activity</subject><subject>antibacterial properties</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Bacteriophages</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Gastroenteritis</subject><subject>genome</subject><subject>Genomes</subject><subject>Genomics</subject><subject>human health</subject><subject>Humans</subject><subject>Laboratories</subject><subject>lifestyle</subject><subject>Medical Microbiology</subject><subject>Metagenomics</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus</subject><subject>Multidrug resistance</subject><subject>multiple drug resistance</subject><subject>Original Paper</subject><subject>Phages</subject><subject>Phietavirus</subject><subject>Plant Sciences</subject><subject>prediction</subject><subject>Public health</subject><subject>Siphoviridae</subject><subject>Staphylococcal Infections - 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In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species
Phietavirus Henu 2
. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus
Phietavirus
, species of
Phietavirus Henu 2
. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant
Staphylococcus aureus
(MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37004601</pmid><doi>10.1007/s11262-023-01990-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Virus genes, 2023-06, Vol.59 (3), p.464-472 |
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| subjects | Antibacterial activity antibacterial properties Antibiotics Bacteria Bacterial infections Bacteriophages Biomedical and Life Sciences Biomedicine DNA Drug resistance Gastroenteritis genome Genomes Genomics human health Humans Laboratories lifestyle Medical Microbiology Metagenomics Methicillin Methicillin-Resistant Staphylococcus aureus Multidrug resistance multiple drug resistance Original Paper Phages Phietavirus Plant Sciences prediction Public health Siphoviridae Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus infections Virology Virome Viruses |
| title | Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis |
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