Oral mucosal vaccination using integrated fiber microneedles

The oral mucosa is an attractive site for immunization due to its accessibility and ability to elicit local and systemic immune responses. However, evaluating oral mucosal immunogenicity has proven challenging due to the physical barriers and immunological complexity of the oral mucosa. Microneedles...

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Veröffentlicht in:	Journal of controlled release 2024-03, Vol.367, p.649-660
Hauptverfasser:	Creighton, Rachel L., Faber, Kate A., Tobos, Carmen I., Doan, My-Anh, Guo, Teri, Woodrow, Kim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Antigens dosage forms Drug Delivery Systems Electrospun fibers geometry immune response Immunity, Mucosal immunogenicity Microneedle Mouth Mucosa mucosa mucosal immunity Mucosal immunization Needles oral administration Oral mucosal delivery Ovalbumin phenotype secretion seroconversion splenocytes vaccination Vaccination - methods Vaccine
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