A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function

Bispecific antibodies (BsAbs) are undergoing continued development for applications in oncology and autoimmune diseases. While increasing activity by having more than one targeting arm, most BsAb engineering employs single Fc engagement as monoclonal antibodies. Here, we designed a novel immunoglobu...

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Veröffentlicht in:	Biochemistry (Easton) 2024-04, Vol.63 (8), p.958-968
Hauptverfasser:	Zhou, Fulai, Ben, Yinyin, Jiang, Hao, Tan, Siwen, Mu, Guangmao, Zha, Zhengxia, Dong, Shuting, Huang, Sheng, Zhou, Yijun, Jin, Ying, Chiu, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	antibodies antigens immunoglobulin G immunotherapy
Online-Zugang:	Volltext
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