Antioxidant, Sun-Protective and Cytotoxic Effects of Chitosan–Glucose Derivatives: A Comparative Study
Chitosan is a versatile and promising polysaccharide with unique properties such as biodegradability, biocompatibility, non-toxicity, and antimicrobial activity, making it attractive for potential applications in various fields including biomedicine, food science, cosmetics, and environmental engine...
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| Veröffentlicht in: | Journal of polymers and the environment 2023-11, Vol.31 (11), p.4875-4890 |
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| creator | Chekanouskaya, Lizaveta Kraskouski, Aliaksandr Hileuskaya, Kseniya Nikalaichuk, Viktoryia Yuzhyk, Liubou Ladutska, Alena Vasilkevich, Vadzim Bogdanov, Ruslan Grekova, Natallia Yao, Wanzi You, Lijun |
| description | Chitosan is a versatile and promising polysaccharide with unique properties such as biodegradability, biocompatibility, non-toxicity, and antimicrobial activity, making it attractive for potential applications in various fields including biomedicine, food science, cosmetics, and environmental engineering. However, its poor solubility and antioxidant activity limits its effectiveness in some applications. In this work, a facile approach for one-pot synthesis of chitosan–glucose derivatives (CG-MRPs) by Maillard reaction using an industrially scalable hydrothermal method was described. Chitosan was functionalized with different percentages of glucose, and the resulting CG-MRPs were characterized by UV–Vis and FTIR spectroscopy, DLS, TGA, and elemental analysis. The CG-MRPs showed a fivefold increase in radical scavenging activity and improved sun-protective effect (sun protection factor 6.30 ± 0.01) compared to the neat chitosan. For the first time, cytotoxicity assays (hen’s egg test on the chorioallantoic membrane, in vivo eye irritation, and test for cytotoxicity on a suspension of bull spermatozoa) of CG-MRPs were performed. In vitro and in vivo toxicity assays confirmed that CG-MRPs had no irritating effect or systemic toxicity. This study suggested that CG-MRPs can be used as biodegradable photoprotective agents in skincare and preservatives in the food and cosmetic industries.
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| doi_str_mv | 10.1007/s10924-023-02921-y |
| format | Article |
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Graphical Abstract</description><identifier>ISSN: 1566-2543</identifier><identifier>EISSN: 1572-8919</identifier><identifier>DOI: 10.1007/s10924-023-02921-y</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antimicrobial activity ; antimicrobial properties ; antioxidant activity ; Antioxidants ; Biocompatibility ; Biodegradability ; Biodegradation ; Biomedical materials ; Chemistry ; Chemistry and Materials Science ; Chitosan ; Chorioallantoic membrane ; Comparative studies ; comparative study ; Cosmetics ; Cytotoxicity ; eggs ; Environmental Chemistry ; Environmental engineering ; Environmental Engineering/Biotechnology ; eye irritation ; Food industry ; Food processing ; food science ; Fourier transform infrared spectroscopy ; Glucose ; hens ; hot water treatment ; In vivo methods and tests ; Industrial Chemistry/Chemical Engineering ; Irritation ; Maillard reaction ; Materials Science ; medicine ; Original Paper ; Polymer Sciences ; Polysaccharides ; Preservatives ; radiation resistance ; Scavenging ; solubility ; Spermatozoa ; synthesis ; Toxicity ; Toxicity testing</subject><ispartof>Journal of polymers and the environment, 2023-11, Vol.31 (11), p.4875-4890</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-f927c832639f4966f206678e1712467c76c9885670448e9360c6e1b1c4801a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10924-023-02921-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10924-023-02921-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Chekanouskaya, Lizaveta</creatorcontrib><creatorcontrib>Kraskouski, Aliaksandr</creatorcontrib><creatorcontrib>Hileuskaya, Kseniya</creatorcontrib><creatorcontrib>Nikalaichuk, Viktoryia</creatorcontrib><creatorcontrib>Yuzhyk, Liubou</creatorcontrib><creatorcontrib>Ladutska, Alena</creatorcontrib><creatorcontrib>Vasilkevich, Vadzim</creatorcontrib><creatorcontrib>Bogdanov, Ruslan</creatorcontrib><creatorcontrib>Grekova, Natallia</creatorcontrib><creatorcontrib>Yao, Wanzi</creatorcontrib><creatorcontrib>You, Lijun</creatorcontrib><title>Antioxidant, Sun-Protective and Cytotoxic Effects of Chitosan–Glucose Derivatives: A Comparative Study</title><title>Journal of polymers and the environment</title><addtitle>J Polym Environ</addtitle><description>Chitosan is a versatile and promising polysaccharide with unique properties such as biodegradability, biocompatibility, non-toxicity, and antimicrobial activity, making it attractive for potential applications in various fields including biomedicine, food science, cosmetics, and environmental engineering. However, its poor solubility and antioxidant activity limits its effectiveness in some applications. In this work, a facile approach for one-pot synthesis of chitosan–glucose derivatives (CG-MRPs) by Maillard reaction using an industrially scalable hydrothermal method was described. Chitosan was functionalized with different percentages of glucose, and the resulting CG-MRPs were characterized by UV–Vis and FTIR spectroscopy, DLS, TGA, and elemental analysis. The CG-MRPs showed a fivefold increase in radical scavenging activity and improved sun-protective effect (sun protection factor 6.30 ± 0.01) compared to the neat chitosan. For the first time, cytotoxicity assays (hen’s egg test on the chorioallantoic membrane, in vivo eye irritation, and test for cytotoxicity on a suspension of bull spermatozoa) of CG-MRPs were performed. In vitro and in vivo toxicity assays confirmed that CG-MRPs had no irritating effect or systemic toxicity. This study suggested that CG-MRPs can be used as biodegradable photoprotective agents in skincare and preservatives in the food and cosmetic industries.
Graphical Abstract</description><subject>Antimicrobial activity</subject><subject>antimicrobial properties</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chitosan</subject><subject>Chorioallantoic membrane</subject><subject>Comparative studies</subject><subject>comparative study</subject><subject>Cosmetics</subject><subject>Cytotoxicity</subject><subject>eggs</subject><subject>Environmental Chemistry</subject><subject>Environmental engineering</subject><subject>Environmental Engineering/Biotechnology</subject><subject>eye irritation</subject><subject>Food industry</subject><subject>Food processing</subject><subject>food science</subject><subject>Fourier transform infrared spectroscopy</subject><subject>Glucose</subject><subject>hens</subject><subject>hot water treatment</subject><subject>In vivo methods and tests</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Irritation</subject><subject>Maillard reaction</subject><subject>Materials Science</subject><subject>medicine</subject><subject>Original Paper</subject><subject>Polymer Sciences</subject><subject>Polysaccharides</subject><subject>Preservatives</subject><subject>radiation resistance</subject><subject>Scavenging</subject><subject>solubility</subject><subject>Spermatozoa</subject><subject>synthesis</subject><subject>Toxicity</subject><subject>Toxicity 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Hileuskaya, Kseniya ; Nikalaichuk, Viktoryia ; Yuzhyk, Liubou ; Ladutska, Alena ; Vasilkevich, Vadzim ; Bogdanov, Ruslan ; Grekova, Natallia ; Yao, Wanzi ; You, Lijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-f927c832639f4966f206678e1712467c76c9885670448e9360c6e1b1c4801a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antimicrobial activity</topic><topic>antimicrobial properties</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chitosan</topic><topic>Chorioallantoic membrane</topic><topic>Comparative studies</topic><topic>comparative study</topic><topic>Cosmetics</topic><topic>Cytotoxicity</topic><topic>eggs</topic><topic>Environmental 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However, its poor solubility and antioxidant activity limits its effectiveness in some applications. In this work, a facile approach for one-pot synthesis of chitosan–glucose derivatives (CG-MRPs) by Maillard reaction using an industrially scalable hydrothermal method was described. Chitosan was functionalized with different percentages of glucose, and the resulting CG-MRPs were characterized by UV–Vis and FTIR spectroscopy, DLS, TGA, and elemental analysis. The CG-MRPs showed a fivefold increase in radical scavenging activity and improved sun-protective effect (sun protection factor 6.30 ± 0.01) compared to the neat chitosan. For the first time, cytotoxicity assays (hen’s egg test on the chorioallantoic membrane, in vivo eye irritation, and test for cytotoxicity on a suspension of bull spermatozoa) of CG-MRPs were performed. In vitro and in vivo toxicity assays confirmed that CG-MRPs had no irritating effect or systemic toxicity. This study suggested that CG-MRPs can be used as biodegradable photoprotective agents in skincare and preservatives in the food and cosmetic industries.
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| subjects | Antimicrobial activity antimicrobial properties antioxidant activity Antioxidants Biocompatibility Biodegradability Biodegradation Biomedical materials Chemistry Chemistry and Materials Science Chitosan Chorioallantoic membrane Comparative studies comparative study Cosmetics Cytotoxicity eggs Environmental Chemistry Environmental engineering Environmental Engineering/Biotechnology eye irritation Food industry Food processing food science Fourier transform infrared spectroscopy Glucose hens hot water treatment In vivo methods and tests Industrial Chemistry/Chemical Engineering Irritation Maillard reaction Materials Science medicine Original Paper Polymer Sciences Polysaccharides Preservatives radiation resistance Scavenging solubility Spermatozoa synthesis Toxicity Toxicity testing |
| title | Antioxidant, Sun-Protective and Cytotoxic Effects of Chitosan–Glucose Derivatives: A Comparative Study |
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