A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels

To identify genetic associations with primary glaucoma (PG) in American Cocker Spaniels using a genome-wide association study (GWAS). A nationwide ambidirectional case-control cohort study was performed in American Cocker Spaniels that had an ophthalmic examination performed by a veterinarian. Ninet...

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Veröffentlicht in:	American journal of veterinary research 2022-11, Vol.83 (11), p.1-8
Hauptverfasser:	Gomes, Filipe Espinheira, Casanova, Maria Isabel, Mouttham, Lara, Bannasch, Danika L, Park, Sangwan, Kim, Soohyun, Young, Laura J, Daley, Nicole L, Thomasy, Sara M, Castelhano, Marta G, Ledbetter, Eric C, Holmberg, Bradford, Boyd, Ryan, Van Der Woerdt, Alexandra, McDonald, Jessica, Hayward, Jessica J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood blood sampling Case-Control Studies Cocker Spaniel cohort studies data quality DNA Dog Diseases - genetics Dogs extracellular matrix Extracellular Matrix Proteins - genetics Genetic Loci Genetic Predisposition to Disease genome-wide association study Genome-Wide Association Study - veterinary Genotype genotyping glaucoma Glaucoma - genetics Glaucoma - veterinary Glaucoma, Open-Angle - genetics Glaucoma, Open-Angle - veterinary humans linkage disequilibrium loci phenotype Polymorphism, Single Nucleotide pruning quality control statistical models veterinarians veterinary medicine
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