Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine
We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant po...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-02, Vol.222, p.113133, Article 113133 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
| container_volume | 222 |
| creator | Lebedev, Vasiliy T. Charykov, Nikolay A. Shemchuk, Olga S. Murin, Igor V. Nerukh, Dmitry A. Petrov, Andrey V. Maystrenko, Dmitriy N. Molchanov, Oleg E. Sharoyko, Vladimir V. Semenov, Konstantin N. |
| description | We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.
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•Endometallofullerenes demonstrate unique structural and physicochemical properties.•The review considered methods for the obtaining and functionalization of EMF.•EMF have the potential for photodynamic therapy and theranostics. |
| doi_str_mv | 10.1016/j.colsurfb.2023.113133 |
| format | Article |
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•Endometallofullerenes demonstrate unique structural and physicochemical properties.•The review considered methods for the obtaining and functionalization of EMF.•EMF have the potential for photodynamic therapy and theranostics.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2023.113133</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>angiogenesis ; antineoplastic agents ; encapsulation ; Endometallofullerenes ; Functionalization ; immune response ; medicine ; metastasis ; MRI-diagnostic ; nanomaterials ; neoplasms ; Physicochemical properties</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2023-02, Vol.222, p.113133, Article 113133</ispartof><rights>2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-a43e31b173f016caaae752df3582fc89aab9ed1787596a3e37f9e16c113ec38a3</citedby><cites>FETCH-LOGICAL-c345t-a43e31b173f016caaae752df3582fc89aab9ed1787596a3e37f9e16c113ec38a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0927776523000115$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Lebedev, Vasiliy T.</creatorcontrib><creatorcontrib>Charykov, Nikolay A.</creatorcontrib><creatorcontrib>Shemchuk, Olga S.</creatorcontrib><creatorcontrib>Murin, Igor V.</creatorcontrib><creatorcontrib>Nerukh, Dmitry A.</creatorcontrib><creatorcontrib>Petrov, Andrey V.</creatorcontrib><creatorcontrib>Maystrenko, Dmitriy N.</creatorcontrib><creatorcontrib>Molchanov, Oleg E.</creatorcontrib><creatorcontrib>Sharoyko, Vladimir V.</creatorcontrib><creatorcontrib>Semenov, Konstantin N.</creatorcontrib><title>Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine</title><title>Colloids and surfaces, B, Biointerfaces</title><description>We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.
[Display omitted]
•Endometallofullerenes demonstrate unique structural and physicochemical properties.•The review considered methods for the obtaining and functionalization of EMF.•EMF have the potential for photodynamic therapy and theranostics.</description><subject>angiogenesis</subject><subject>antineoplastic agents</subject><subject>encapsulation</subject><subject>Endometallofullerenes</subject><subject>Functionalization</subject><subject>immune response</subject><subject>medicine</subject><subject>metastasis</subject><subject>MRI-diagnostic</subject><subject>nanomaterials</subject><subject>neoplasms</subject><subject>Physicochemical properties</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkE9PwyAYh4nRxDn9CoajB1tLaUvrSbPMP8kSD-qZMPo2excKFbolu_jZpZmePRHg-b3wewi5ZlnKMlbdbVPtTNj5bp3mWc5Txjjj_ITMWC14UvBKnJJZ1uQiEaIqz8lFCNssy_KCiRn5XtrW9TAqY1y3MwY8WAhU2ZaOG0BPW_C4VyPuIdzT94ONpwHDLR02h4Da6Q30qJWhg3cD-BEh3k3puAkD6ClI1TCYCI3oLEVL1xhfbFGjhUty1ikT4Op3nZPPp-XH4iVZvT2_Lh5XieZFOSaq4MDZmgnexcZaKQWizNuOl3Xe6bpRat1Ay0QtyqZSkRVdAxGMKkDzWvE5uTnOjd_82kEYZY9BgzHKgtsFyVnJWV0VBY9odUS1dyF46OTgsVf-IFkmJ-FyK_-Ey0m4PAqPwYdjEGKRPYKXQSNYHav6KEK2Dv8b8QOWiJEz</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Lebedev, Vasiliy T.</creator><creator>Charykov, Nikolay A.</creator><creator>Shemchuk, Olga S.</creator><creator>Murin, Igor V.</creator><creator>Nerukh, Dmitry A.</creator><creator>Petrov, Andrey V.</creator><creator>Maystrenko, Dmitriy N.</creator><creator>Molchanov, Oleg E.</creator><creator>Sharoyko, Vladimir V.</creator><creator>Semenov, Konstantin N.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202302</creationdate><title>Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine</title><author>Lebedev, Vasiliy T. ; Charykov, Nikolay A. ; Shemchuk, Olga S. ; Murin, Igor V. ; Nerukh, Dmitry A. ; Petrov, Andrey V. ; Maystrenko, Dmitriy N. ; Molchanov, Oleg E. ; Sharoyko, Vladimir V. ; Semenov, Konstantin N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-a43e31b173f016caaae752df3582fc89aab9ed1787596a3e37f9e16c113ec38a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>angiogenesis</topic><topic>antineoplastic agents</topic><topic>encapsulation</topic><topic>Endometallofullerenes</topic><topic>Functionalization</topic><topic>immune response</topic><topic>medicine</topic><topic>metastasis</topic><topic>MRI-diagnostic</topic><topic>nanomaterials</topic><topic>neoplasms</topic><topic>Physicochemical properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lebedev, Vasiliy T.</creatorcontrib><creatorcontrib>Charykov, Nikolay A.</creatorcontrib><creatorcontrib>Shemchuk, Olga S.</creatorcontrib><creatorcontrib>Murin, Igor V.</creatorcontrib><creatorcontrib>Nerukh, Dmitry A.</creatorcontrib><creatorcontrib>Petrov, Andrey V.</creatorcontrib><creatorcontrib>Maystrenko, Dmitriy N.</creatorcontrib><creatorcontrib>Molchanov, Oleg E.</creatorcontrib><creatorcontrib>Sharoyko, Vladimir V.</creatorcontrib><creatorcontrib>Semenov, Konstantin N.</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lebedev, Vasiliy T.</au><au>Charykov, Nikolay A.</au><au>Shemchuk, Olga S.</au><au>Murin, Igor V.</au><au>Nerukh, Dmitry A.</au><au>Petrov, Andrey V.</au><au>Maystrenko, Dmitriy N.</au><au>Molchanov, Oleg E.</au><au>Sharoyko, Vladimir V.</au><au>Semenov, Konstantin N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><date>2023-02</date><risdate>2023</risdate><volume>222</volume><spage>113133</spage><pages>113133-</pages><artnum>113133</artnum><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.
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•Endometallofullerenes demonstrate unique structural and physicochemical properties.•The review considered methods for the obtaining and functionalization of EMF.•EMF have the potential for photodynamic therapy and theranostics.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.colsurfb.2023.113133</doi></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2023-02, Vol.222, p.113133, Article 113133 |
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| source | Elsevier ScienceDirect Journals |
| subjects | angiogenesis antineoplastic agents encapsulation Endometallofullerenes Functionalization immune response medicine metastasis MRI-diagnostic nanomaterials neoplasms Physicochemical properties |
| title | Endometallofullerenes and their derivatives: Synthesis, physicochemical properties, and perspective application in biomedicine |
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