Mechanistic Insights of Copper Catalyzed Trifluoromethyl Aziridine Opening: Regioselective and Stereospecific Aryl Grignard Addition

The copper catalyzed regioselective and stereospecific opening of CF3-aziridines is reported. This method focuses on the synthesis of α-CF3-β-arylethylamines, which can be potential key intermediates in the synthesis of synthetic analogues and biologically active molecules. Density functional theory...

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Veröffentlicht in:	Organic letters 2024-04, Vol.26 (14), p.2713-2717
Hauptverfasser:	Lee, Miseon, Sulwey, Dennis, Rotella, Madeline E., Kim, Wan Shin, Ju, Xuan, Jiang, Qi, Kozlowski, Marisa C., Lee, Jaehee
Format:	Artikel
Sprache:	eng
Schlagworte:	copper density functional theory ethyleneimine Lewis acids regioselectivity stereospecificity
Online-Zugang:	Volltext
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