The combination of Alisma and Atractylodes ameliorates cerebral ischaemia/reperfusion injury by negatively regulating astrocyte-derived exosomal miR-200a-3p/141-3p by targeting SIRT1

The combination of Alisma and Atractylodes (AA), a classical traditional Chinese herbal decoction, may protect against cerebral ischaemia/reperfusion injury (CIRI). However, the underlying mechanism has not been characterized. Intriguingly, exosomal microRNAs (miRNAs) have been recognized as vital f...

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Veröffentlicht in:	Journal of ethnopharmacology 2023-09, Vol.313, p.116597-116597, Article 116597
Hauptverfasser:	Wei, Wei, Li, Huihong, Deng, Yunfei, Zheng, Xiaoqing, Zhou, Yangjie, Xue, Xiehua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alisma Alisma - genetics Alisma - metabolism Alisma and atractylodes Animals Apoptosis Astrocytes - metabolism Atractylodes blood-brain barrier Brain Ischemia - metabolism carotid arteries cerebral cortex Cerebral ischaemia/reperfusion injury Endothelial Cells - metabolism enzyme-linked immunosorbent assay Exosomal miR-200a-3p/141-3p exosomes fluorescent dyes genes glucose immunohistochemistry ischemia memory disorders Mice Mice, Inbred C57BL microarray technology microRNA MicroRNAs - metabolism nanoparticles necrosis neoplasms neuroprotective effect NF-kappa B Occludin occludins oxygen permeability protein synthesis quantitative polymerase chain reaction reperfusion injury Reperfusion Injury - metabolism SIRT1 Sirtuin 1 - genetics sirtuins traditional medicine transmission electron microscopy Tumor Necrosis Factor-alpha - pharmacology ultracentrifugation Western blotting
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