18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis

Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific non-genetic cues are transmitted from parents to their descendants are poorly understood. Here, we perform metabolic methyl-labeling experiments to track the heritable transmission of methylation f...

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Veröffentlicht in:	Molecular cell 2023-09, Vol.83 (18), p.3268-3282.e7
Hauptverfasser:	Liberman, Noa, Rothi, M. Hafiz, Gerashchenko, Maxim V., Zorbas, Christiane, Boulias, Konstantinos, MacWhinnie, Fiona G., Ying, Albert Kejun, Flood Taylor, Anya, Al Haddad, Joseph, Shibuya, Hiroki, Roach, Lara, Dong, Anna, Dellacona, Scarlett, Lafontaine, Denis L.J., Gladyshev, Vadim N., Greer, Eric Lieberman
Format:	Artikel
Sprache:	eng
Schlagworte:	18S rRNA adenosine Caenorhabditis elegans DIMT1 DNA epigenetics heat stress heritable methylation hormesis intergenerational longevity methylation methyltransferases progeny ribosomal RNA rRNA methylation starvation stress tolerance transgenerational WBSCR22/BUD23
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