Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7
A novel endophytic fungus producing beta-glucosidase was isolated and characterized from pigeon pea ( Cajanus cajan [L.] Millsp.), which has excellent properties in converting ginsenoside Rb1 to ginsenoside Rd in Panax notoginseng . According to the 16S rDNA gene sequence, the G11-7 strain was ident...
Gespeichert in:
| Veröffentlicht in: | Folia microbiologica 2023-06, Vol.68 (3), p.441-452 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 452 |
|---|---|
| container_issue | 3 |
| container_start_page | 441 |
| container_title | Folia microbiologica |
| container_volume | 68 |
| creator | Niu, Lili Qin, Xiangyu Wang, Litao Guo, Na Cao, Hongyan Li, Hanghang Zhao, Chunjian Wang, Huimei Fu, Yujie |
| description | A novel endophytic fungus producing beta-glucosidase was isolated and characterized from pigeon pea (
Cajanus cajan
[L.] Millsp.), which has excellent properties in converting ginsenoside Rb1 to ginsenoside Rd in
Panax notoginseng
. According to the 16S rDNA gene sequence, the G11-7 strain was identified as
Fusarium proliferatum
, and the accession number KY303906 was confirmed in GenBank. The G11-7 immobilized spores, in which the activity of beta-glucosidase could reach 0.95 U/mL, were co-cultured with
P. notoginseng
plant material to obtain a continuous beta-glucosidase supply for the biotransformation of ginsenoside Rb1 to Rd. Under the liquid–solid ratio (20:1), initial pH (6.0), and temperature (30 °C) constituents, the maximum ginsenoside Rd yield was obtained as 9.15 ± 0.65 mg/g, which was 3.67-fold higher than that without fungal spore co-culture (2.49 ± 0.98 mg/g). Furthermore, immobilized G11-7 spores showed significant beta-glucosidase producing ability which could be recovered and reused for 6 cycles. Overall, these results suggested that immobilized G11-7 offered a promising and effective approach to enhance the production of ginsenoside Rd for possible nutraceutical and pharmaceutical uses. |
| doi_str_mv | 10.1007/s12223-022-01020-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153173540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2817904551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-7168aea4f7df54cb6446aa71dc27c60aa46abdd28ab5b6ab9b9d2859a71c92b93</originalsourceid><addsrcrecordid>eNqFkUGP1SAUhYnROM_RP-DCkLhxg16glLI0Ex1NJtEYZ01ugXY66YNnKcbnr5dnR01c6Aou9-PcA4eQpxxecgD9KnMhhGQgBAMOAhjcIzve6YYZqdr7ZAfAFVOtFGfkUc63AC00UjwkZ7JVmrda7cj368O4oJ_iSNebQNG5si8zrlOKNA10nGIOMeXJB_rJ0ynSjxjxG41pTVtvpP2RYj34GmY6zkd3gjEHdliSL-4kHKJPh5vjOjk6lDiWTC85Z_oxeTDgnMOTu_WcXL998_niHbv6cPn-4vUVc1KZlVWjHQZsBu0H1bi-bZoWUXPvhHYtINay91502Ku-bk1vaqFMRZwRvZHn5MWmWx19KSGvdj9lF-YZY0glW8mV5FqqBv6LCq26-rXCiIo-_wu9TWWJ9SFWdFwbaJTilRIb5ZaU8xIGe1imPS5Hy8GeQrRbiLaGaH-GaE8unt1Jl34f_O8rv1KrgNyAXFtxDMuf2f-Q_QGpoqfq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2817904551</pqid></control><display><type>article</type><title>Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Niu, Lili ; Qin, Xiangyu ; Wang, Litao ; Guo, Na ; Cao, Hongyan ; Li, Hanghang ; Zhao, Chunjian ; Wang, Huimei ; Fu, Yujie</creator><creatorcontrib>Niu, Lili ; Qin, Xiangyu ; Wang, Litao ; Guo, Na ; Cao, Hongyan ; Li, Hanghang ; Zhao, Chunjian ; Wang, Huimei ; Fu, Yujie</creatorcontrib><description>A novel endophytic fungus producing beta-glucosidase was isolated and characterized from pigeon pea (
Cajanus cajan
[L.] Millsp.), which has excellent properties in converting ginsenoside Rb1 to ginsenoside Rd in
Panax notoginseng
. According to the 16S rDNA gene sequence, the G11-7 strain was identified as
Fusarium proliferatum
, and the accession number KY303906 was confirmed in GenBank. The G11-7 immobilized spores, in which the activity of beta-glucosidase could reach 0.95 U/mL, were co-cultured with
P. notoginseng
plant material to obtain a continuous beta-glucosidase supply for the biotransformation of ginsenoside Rb1 to Rd. Under the liquid–solid ratio (20:1), initial pH (6.0), and temperature (30 °C) constituents, the maximum ginsenoside Rd yield was obtained as 9.15 ± 0.65 mg/g, which was 3.67-fold higher than that without fungal spore co-culture (2.49 ± 0.98 mg/g). Furthermore, immobilized G11-7 spores showed significant beta-glucosidase producing ability which could be recovered and reused for 6 cycles. Overall, these results suggested that immobilized G11-7 offered a promising and effective approach to enhance the production of ginsenoside Rd for possible nutraceutical and pharmaceutical uses.</description><identifier>ISSN: 0015-5632</identifier><identifier>EISSN: 1874-9356</identifier><identifier>DOI: 10.1007/s12223-022-01020-0</identifier><identifier>PMID: 36571675</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Applied Microbiology ; beta-glucosidase ; beta-Glucosidase - metabolism ; Biomedical and Life Sciences ; Biotransformation ; Cajanus cajan ; coculture ; dietary supplements ; Efficiency ; Endophytes ; Environmental Engineering/Biotechnology ; Enzymes ; Food ; Forestry ; Functional foods & nutraceuticals ; fungal spores ; Fungi ; Fungi - metabolism ; Fusarium proliferatum ; Ginsenosides ; Glucosidase ; Glycosidases ; Glycoside Hydrolases - metabolism ; Herbal medicine ; Immunology ; Life Sciences ; Microbiology ; nucleotide sequences ; Original Article ; Panax notoginseng ; Phylogenetics ; pigeon peas ; Pigeonpeas ; rRNA 16S ; Spores ; temperature ; β-Glucosidase</subject><ispartof>Folia microbiologica, 2023-06, Vol.68 (3), p.441-452</ispartof><rights>Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-7168aea4f7df54cb6446aa71dc27c60aa46abdd28ab5b6ab9b9d2859a71c92b93</cites><orcidid>0000-0002-8318-2668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12223-022-01020-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12223-022-01020-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36571675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niu, Lili</creatorcontrib><creatorcontrib>Qin, Xiangyu</creatorcontrib><creatorcontrib>Wang, Litao</creatorcontrib><creatorcontrib>Guo, Na</creatorcontrib><creatorcontrib>Cao, Hongyan</creatorcontrib><creatorcontrib>Li, Hanghang</creatorcontrib><creatorcontrib>Zhao, Chunjian</creatorcontrib><creatorcontrib>Wang, Huimei</creatorcontrib><creatorcontrib>Fu, Yujie</creatorcontrib><title>Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7</title><title>Folia microbiologica</title><addtitle>Folia Microbiol</addtitle><addtitle>Folia Microbiol (Praha)</addtitle><description>A novel endophytic fungus producing beta-glucosidase was isolated and characterized from pigeon pea (
Cajanus cajan
[L.] Millsp.), which has excellent properties in converting ginsenoside Rb1 to ginsenoside Rd in
Panax notoginseng
. According to the 16S rDNA gene sequence, the G11-7 strain was identified as
Fusarium proliferatum
, and the accession number KY303906 was confirmed in GenBank. The G11-7 immobilized spores, in which the activity of beta-glucosidase could reach 0.95 U/mL, were co-cultured with
P. notoginseng
plant material to obtain a continuous beta-glucosidase supply for the biotransformation of ginsenoside Rb1 to Rd. Under the liquid–solid ratio (20:1), initial pH (6.0), and temperature (30 °C) constituents, the maximum ginsenoside Rd yield was obtained as 9.15 ± 0.65 mg/g, which was 3.67-fold higher than that without fungal spore co-culture (2.49 ± 0.98 mg/g). Furthermore, immobilized G11-7 spores showed significant beta-glucosidase producing ability which could be recovered and reused for 6 cycles. Overall, these results suggested that immobilized G11-7 offered a promising and effective approach to enhance the production of ginsenoside Rd for possible nutraceutical and pharmaceutical uses.</description><subject>Applied Microbiology</subject><subject>beta-glucosidase</subject><subject>beta-Glucosidase - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biotransformation</subject><subject>Cajanus cajan</subject><subject>coculture</subject><subject>dietary supplements</subject><subject>Efficiency</subject><subject>Endophytes</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Enzymes</subject><subject>Food</subject><subject>Forestry</subject><subject>Functional foods & nutraceuticals</subject><subject>fungal spores</subject><subject>Fungi</subject><subject>Fungi - metabolism</subject><subject>Fusarium proliferatum</subject><subject>Ginsenosides</subject><subject>Glucosidase</subject><subject>Glycosidases</subject><subject>Glycoside Hydrolases - metabolism</subject><subject>Herbal medicine</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>nucleotide sequences</subject><subject>Original Article</subject><subject>Panax notoginseng</subject><subject>Phylogenetics</subject><subject>pigeon peas</subject><subject>Pigeonpeas</subject><subject>rRNA 16S</subject><subject>Spores</subject><subject>temperature</subject><subject>β-Glucosidase</subject><issn>0015-5632</issn><issn>1874-9356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUGP1SAUhYnROM_RP-DCkLhxg16glLI0Ex1NJtEYZ01ugXY66YNnKcbnr5dnR01c6Aou9-PcA4eQpxxecgD9KnMhhGQgBAMOAhjcIzve6YYZqdr7ZAfAFVOtFGfkUc63AC00UjwkZ7JVmrda7cj368O4oJ_iSNebQNG5si8zrlOKNA10nGIOMeXJB_rJ0ynSjxjxG41pTVtvpP2RYj34GmY6zkd3gjEHdliSL-4kHKJPh5vjOjk6lDiWTC85Z_oxeTDgnMOTu_WcXL998_niHbv6cPn-4vUVc1KZlVWjHQZsBu0H1bi-bZoWUXPvhHYtINay91502Ku-bk1vaqFMRZwRvZHn5MWmWx19KSGvdj9lF-YZY0glW8mV5FqqBv6LCq26-rXCiIo-_wu9TWWJ9SFWdFwbaJTilRIb5ZaU8xIGe1imPS5Hy8GeQrRbiLaGaH-GaE8unt1Jl34f_O8rv1KrgNyAXFtxDMuf2f-Q_QGpoqfq</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Niu, Lili</creator><creator>Qin, Xiangyu</creator><creator>Wang, Litao</creator><creator>Guo, Na</creator><creator>Cao, Hongyan</creator><creator>Li, Hanghang</creator><creator>Zhao, Chunjian</creator><creator>Wang, Huimei</creator><creator>Fu, Yujie</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-8318-2668</orcidid></search><sort><creationdate>20230601</creationdate><title>Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7</title><author>Niu, Lili ; Qin, Xiangyu ; Wang, Litao ; Guo, Na ; Cao, Hongyan ; Li, Hanghang ; Zhao, Chunjian ; Wang, Huimei ; Fu, Yujie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-7168aea4f7df54cb6446aa71dc27c60aa46abdd28ab5b6ab9b9d2859a71c92b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Applied Microbiology</topic><topic>beta-glucosidase</topic><topic>beta-Glucosidase - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biotransformation</topic><topic>Cajanus cajan</topic><topic>coculture</topic><topic>dietary supplements</topic><topic>Efficiency</topic><topic>Endophytes</topic><topic>Environmental Engineering/Biotechnology</topic><topic>Enzymes</topic><topic>Food</topic><topic>Forestry</topic><topic>Functional foods & nutraceuticals</topic><topic>fungal spores</topic><topic>Fungi</topic><topic>Fungi - metabolism</topic><topic>Fusarium proliferatum</topic><topic>Ginsenosides</topic><topic>Glucosidase</topic><topic>Glycosidases</topic><topic>Glycoside Hydrolases - metabolism</topic><topic>Herbal medicine</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>nucleotide sequences</topic><topic>Original Article</topic><topic>Panax notoginseng</topic><topic>Phylogenetics</topic><topic>pigeon peas</topic><topic>Pigeonpeas</topic><topic>rRNA 16S</topic><topic>Spores</topic><topic>temperature</topic><topic>β-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niu, Lili</creatorcontrib><creatorcontrib>Qin, Xiangyu</creatorcontrib><creatorcontrib>Wang, Litao</creatorcontrib><creatorcontrib>Guo, Na</creatorcontrib><creatorcontrib>Cao, Hongyan</creatorcontrib><creatorcontrib>Li, Hanghang</creatorcontrib><creatorcontrib>Zhao, Chunjian</creatorcontrib><creatorcontrib>Wang, Huimei</creatorcontrib><creatorcontrib>Fu, Yujie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Folia microbiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niu, Lili</au><au>Qin, Xiangyu</au><au>Wang, Litao</au><au>Guo, Na</au><au>Cao, Hongyan</au><au>Li, Hanghang</au><au>Zhao, Chunjian</au><au>Wang, Huimei</au><au>Fu, Yujie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7</atitle><jtitle>Folia microbiologica</jtitle><stitle>Folia Microbiol</stitle><addtitle>Folia Microbiol (Praha)</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>68</volume><issue>3</issue><spage>441</spage><epage>452</epage><pages>441-452</pages><issn>0015-5632</issn><eissn>1874-9356</eissn><abstract>A novel endophytic fungus producing beta-glucosidase was isolated and characterized from pigeon pea (
Cajanus cajan
[L.] Millsp.), which has excellent properties in converting ginsenoside Rb1 to ginsenoside Rd in
Panax notoginseng
. According to the 16S rDNA gene sequence, the G11-7 strain was identified as
Fusarium proliferatum
, and the accession number KY303906 was confirmed in GenBank. The G11-7 immobilized spores, in which the activity of beta-glucosidase could reach 0.95 U/mL, were co-cultured with
P. notoginseng
plant material to obtain a continuous beta-glucosidase supply for the biotransformation of ginsenoside Rb1 to Rd. Under the liquid–solid ratio (20:1), initial pH (6.0), and temperature (30 °C) constituents, the maximum ginsenoside Rd yield was obtained as 9.15 ± 0.65 mg/g, which was 3.67-fold higher than that without fungal spore co-culture (2.49 ± 0.98 mg/g). Furthermore, immobilized G11-7 spores showed significant beta-glucosidase producing ability which could be recovered and reused for 6 cycles. Overall, these results suggested that immobilized G11-7 offered a promising and effective approach to enhance the production of ginsenoside Rd for possible nutraceutical and pharmaceutical uses.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36571675</pmid><doi>10.1007/s12223-022-01020-0</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8318-2668</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-5632 |
| ispartof | Folia microbiologica, 2023-06, Vol.68 (3), p.441-452 |
| issn | 0015-5632 1874-9356 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153173540 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Applied Microbiology beta-glucosidase beta-Glucosidase - metabolism Biomedical and Life Sciences Biotransformation Cajanus cajan coculture dietary supplements Efficiency Endophytes Environmental Engineering/Biotechnology Enzymes Food Forestry Functional foods & nutraceuticals fungal spores Fungi Fungi - metabolism Fusarium proliferatum Ginsenosides Glucosidase Glycosidases Glycoside Hydrolases - metabolism Herbal medicine Immunology Life Sciences Microbiology nucleotide sequences Original Article Panax notoginseng Phylogenetics pigeon peas Pigeonpeas rRNA 16S Spores temperature β-Glucosidase |
| title | Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T08%3A04%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Upgrading%20the%20accumulation%20of%20ginsenoside%20Rd%20in%20Panax%20notoginseng%20by%20a%20novel%20glycosidase-producing%20endophytic%20fungus%20G11-7&rft.jtitle=Folia%20microbiologica&rft.au=Niu,%20Lili&rft.date=2023-06-01&rft.volume=68&rft.issue=3&rft.spage=441&rft.epage=452&rft.pages=441-452&rft.issn=0015-5632&rft.eissn=1874-9356&rft_id=info:doi/10.1007/s12223-022-01020-0&rft_dat=%3Cproquest_cross%3E2817904551%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2817904551&rft_id=info:pmid/36571675&rfr_iscdi=true |