Ordered mesoporous silicas for potential applications in solid vaccine formulations

•Immunogenic Activity Study: Exploring how solvent removal impacts the immunogenic activity of vaccine antigens in SBA-15.•Effective antigen incorporation: The study shows BSA in SBA-15 enhances immunogenicity, surpassing pure antigen.•Powdered Storage Potential: SBA-15:BSA, a promising solid vaccin...

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Veröffentlicht in:	Vaccine 2024-01, Vol.42 (3), p.689-700
Hauptverfasser:	Miranda, Matheus C.R., Nunes, Carmen M., Santos, Luana F., da Silva, Leonardo B., de Jesus, Vinicius R., Filho, Newton Andréo, Pedro, Jéssica A.F., Lopes, José L.S., Oliveira, Cristiano L.P., Fantini, Marcia C.A., Cardoso, Jessica S., Trezena, Aryene G., Ribeiro, Orlando G., Sant'Anna, Osvaldo A., Tino-De-Franco, Milene, Martins, Tereza S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adequacy Antigens Bovine serum albumin Circular dichroism circular dichroism spectroscopy COVID-19 vaccines Cytokines Dichroism Disease transmission encapsulation Evaporation fluorescence emission spectroscopy Fluorescence spectroscopy Freeze drying Immunogenicity Immunoglobulin G Infectious diseases nitrogen Pandemics Pathogens Pharmaceutical industry Pore size Pore size distribution porosity porous media Preservation Protein structure Proteins Public health Residues SBA-15 Secondary structure Silica Silicon dioxide Size distribution small-angle X-ray scattering Solid vaccine solvents sorption isotherms Spectra Surface area Toxicity Tryptophan Vaccine adjuvant Vaccines X-ray scattering
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