The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila

Notch signaling controls numerous key cellular processes including cell fate determination and cell proliferation. Its malfunction has been linked to many developmental abnormalities and human disorders. Overactivation of Notch signaling is shown to be oncogenic. Retention of excess Notch protein in...

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Veröffentlicht in:	Developmental biology 2024-03, Vol.507, p.11-19
Hauptverfasser:	Li, Yu, Liu, Dongyue, Wang, Haochuan, Zhang, Xuejing, Lu, Bingwei, Li, Shuangxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences cell proliferation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - metabolism Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism endoplasmic reticulum Endoplasmic reticulum (ER) Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - genetics Endoribonucleases - genetics Endoribonucleases - metabolism eyes gain-of-function mutation Homeostasis Humans IRE1 Notch phenotype Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism Unfolded Protein Response Unfolded protein response (UPR)
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