Insight into the mechanism of Xiao–Chai–Hu–Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS

•Xiao–Chai–Hu–Tang attenuates irinotecan-induced diarrhea by mediating gut microbiota.•Xiao–Chai–Hu–Tang attenuates irinotecan-induced diarrhea by inhibiting gut β-GUS.•Xiao–Chai–Hu–Tang significantly reduced the concentration of SN-38 in the gut.•Xiao–Chai–Hu–Tang active ingredient baicalein select...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-11, Vol.120, p.155040-155040, Article 155040
Hauptverfasser:	Wang, Caiyan, Teng, Xiaojun, Wang, Chuang, Liu, Binjie, Zhou, Runze, Xu, Xueyu, Qiu, Huawei, Fu, Yu, Sun, Rongjin, Liang, Zuhui, Zhang, Rong, Liu, Zhongqiu, Zhang, Lin, Zhu, Lijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic activity colorectal neoplasms CPT-11-induced diarrhea cytokines diarrhea drugs enzyme activity Firmicutes Gut microbiota inflammation ingredients intestinal microorganisms intestines metastasis Molecular interaction toxicity X-ray diffraction Xiao–Chai–Hu–Tang β-glucuronidase
Online-Zugang:	Volltext
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