Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China
Children are highly vulnerable to environmental pollutants, especially endocrine-disrupting chemicals (EDCs). Previous research has linked both organic UV filters and phthalates exposure to adiposity and pubertal development in children. Nevertheless, the individual and collective effects of these c...
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| Veröffentlicht in: | The Science of the total environment 2023-12, Vol.905, p.167433-167433, Article 167433 |
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| container_title | The Science of the total environment |
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| creator | Huang, Yanran Wang, Pengpeng Peng, Weiyu Law, Japhet Cheuk-Fung Zhang, Liyi Shi, Huijing Zhang, Yunhui Leung, Kelvin Sze-Yin |
| description | Children are highly vulnerable to environmental pollutants, especially endocrine-disrupting chemicals (EDCs). Previous research has linked both organic UV filters and phthalates exposure to adiposity and pubertal development in children. Nevertheless, the individual and collective effects of these chemicals on this population remain poorly understood. In this study, twelve organic UV filters and metabolites, six phthalate metabolites and two oxidative stress biomarkers were analyzed in a prospective follow-up study in Shanghai, China after a baseline study conducted 1.5 years earlier. Results revealed a positive association between exposure to individual organic UV filters or their mixture and levels of 8-OHdG (β ranging from 0.242 to 0.588, P |
| doi_str_mv | 10.1016/j.scitotenv.2023.167433 |
| format | Article |
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[Display omitted]
•Individual organic UV filters and their mixture are associated with elevated 8-OHdG.•BP-3 and OD-PABA are the dominant contributors of the mixture effect on 8-OHdG.•Stratified analysis shows gender differences.•Mixture of organic UV filters is associated with decreased HNE-MA level.•Co-exposure elevates 8-OHdG level which exhibits cumulative risks.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2023.167433</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>adiposity ; biomarkers ; China ; DNA damage ; Endocrine disruptors ; environment ; metabolites ; Mixture analysis ; oxidative stress ; Oxidative stress biomarkers ; phthalates ; Prospective follow-up study</subject><ispartof>The Science of the total environment, 2023-12, Vol.905, p.167433-167433, Article 167433</ispartof><rights>2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c327t-50c6ab925a80c0678c61c8886d20cf09ce08fe9850272e60adc3d6ca66086cca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0048969723060606$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Huang, Yanran</creatorcontrib><creatorcontrib>Wang, Pengpeng</creatorcontrib><creatorcontrib>Peng, Weiyu</creatorcontrib><creatorcontrib>Law, Japhet Cheuk-Fung</creatorcontrib><creatorcontrib>Zhang, Liyi</creatorcontrib><creatorcontrib>Shi, Huijing</creatorcontrib><creatorcontrib>Zhang, Yunhui</creatorcontrib><creatorcontrib>Leung, Kelvin Sze-Yin</creatorcontrib><title>Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China</title><title>The Science of the total environment</title><description>Children are highly vulnerable to environmental pollutants, especially endocrine-disrupting chemicals (EDCs). Previous research has linked both organic UV filters and phthalates exposure to adiposity and pubertal development in children. Nevertheless, the individual and collective effects of these chemicals on this population remain poorly understood. In this study, twelve organic UV filters and metabolites, six phthalate metabolites and two oxidative stress biomarkers were analyzed in a prospective follow-up study in Shanghai, China after a baseline study conducted 1.5 years earlier. Results revealed a positive association between exposure to individual organic UV filters or their mixture and levels of 8-OHdG (β ranging from 0.242 to 0.588, P < 0.05), a marker of oxidative DNA damage. BP-3 and OD-PABA made a greater contribution to oxidative DNA damage than other UV filters. Levels of 8-OHdG were also positively correlated with single phthalate metabolites and their mixture, with MnBP and MMP contributing the most. Stratified analysis found that these associations were mainly observed in girls. Our mixture analysis revealed cumulative risks of oxidative DNA damage when there was co-exposure to these two kinds of EDCs. These results underscore the importance of considering the risks associated with organic UV filters and the necessity of evaluating the effects of all these pollutants, both individually and in mixtures.
[Display omitted]
•Individual organic UV filters and their mixture are associated with elevated 8-OHdG.•BP-3 and OD-PABA are the dominant contributors of the mixture effect on 8-OHdG.•Stratified analysis shows gender differences.•Mixture of organic UV filters is associated with decreased HNE-MA level.•Co-exposure elevates 8-OHdG level which exhibits cumulative risks.</description><subject>adiposity</subject><subject>biomarkers</subject><subject>China</subject><subject>DNA damage</subject><subject>Endocrine disruptors</subject><subject>environment</subject><subject>metabolites</subject><subject>Mixture analysis</subject><subject>oxidative stress</subject><subject>Oxidative stress biomarkers</subject><subject>phthalates</subject><subject>Prospective follow-up study</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkcFu1DAQhiMEEkvhGfCRS5axs-vY3FYrKEiVuFCulhlPiFeuHWxn274Jj0uWIK6dy2ik7x_N_H_TvOWw5cDl-9O2oK-pUjxvBYhuy2W_67pnzYarXrcchHzebAB2qtVS9y-bV6WcYKle8U3z-5haephSmTOxmljKP230yG6_s8GHSrkwGx2bxjraYCutYx3JZ2ZLSeht9SkWdu_ryNKDd8t8JlZqplJYoDOFwnxkOPrgMsUP7MCmnMpE-BccUgjpvp2nRTK7xwt6HH20r5sXgw2F3vzrV83tp4_fjp_bm6_XX46HmxY70dd2DyjtDy32VgGC7BVKjkop6QTgABoJ1EBa7UH0giRYh52TaKUEJRFtd9W8W_cuR_2aqVRz5wtSCDZSmovp-L7jO601PIkK1YPWgu_kgvYrisurJdNgpuzvbH40HMwlNnMy_2Mzl9jMGtuiPKzKxTc6e8oXjiKS83mxzLjkn9zxB9TeqH4</recordid><startdate>20231220</startdate><enddate>20231220</enddate><creator>Huang, Yanran</creator><creator>Wang, Pengpeng</creator><creator>Peng, Weiyu</creator><creator>Law, Japhet Cheuk-Fung</creator><creator>Zhang, Liyi</creator><creator>Shi, Huijing</creator><creator>Zhang, Yunhui</creator><creator>Leung, Kelvin Sze-Yin</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20231220</creationdate><title>Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China</title><author>Huang, Yanran ; Wang, Pengpeng ; Peng, Weiyu ; Law, Japhet Cheuk-Fung ; Zhang, Liyi ; Shi, Huijing ; Zhang, Yunhui ; Leung, Kelvin Sze-Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-50c6ab925a80c0678c61c8886d20cf09ce08fe9850272e60adc3d6ca66086cca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>adiposity</topic><topic>biomarkers</topic><topic>China</topic><topic>DNA damage</topic><topic>Endocrine disruptors</topic><topic>environment</topic><topic>metabolites</topic><topic>Mixture analysis</topic><topic>oxidative stress</topic><topic>Oxidative stress biomarkers</topic><topic>phthalates</topic><topic>Prospective follow-up study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yanran</creatorcontrib><creatorcontrib>Wang, Pengpeng</creatorcontrib><creatorcontrib>Peng, Weiyu</creatorcontrib><creatorcontrib>Law, Japhet Cheuk-Fung</creatorcontrib><creatorcontrib>Zhang, Liyi</creatorcontrib><creatorcontrib>Shi, Huijing</creatorcontrib><creatorcontrib>Zhang, Yunhui</creatorcontrib><creatorcontrib>Leung, Kelvin Sze-Yin</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Yanran</au><au>Wang, Pengpeng</au><au>Peng, Weiyu</au><au>Law, Japhet Cheuk-Fung</au><au>Zhang, Liyi</au><au>Shi, Huijing</au><au>Zhang, Yunhui</au><au>Leung, Kelvin Sze-Yin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China</atitle><jtitle>The Science of the total environment</jtitle><date>2023-12-20</date><risdate>2023</risdate><volume>905</volume><spage>167433</spage><epage>167433</epage><pages>167433-167433</pages><artnum>167433</artnum><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Children are highly vulnerable to environmental pollutants, especially endocrine-disrupting chemicals (EDCs). Previous research has linked both organic UV filters and phthalates exposure to adiposity and pubertal development in children. Nevertheless, the individual and collective effects of these chemicals on this population remain poorly understood. In this study, twelve organic UV filters and metabolites, six phthalate metabolites and two oxidative stress biomarkers were analyzed in a prospective follow-up study in Shanghai, China after a baseline study conducted 1.5 years earlier. Results revealed a positive association between exposure to individual organic UV filters or their mixture and levels of 8-OHdG (β ranging from 0.242 to 0.588, P < 0.05), a marker of oxidative DNA damage. BP-3 and OD-PABA made a greater contribution to oxidative DNA damage than other UV filters. Levels of 8-OHdG were also positively correlated with single phthalate metabolites and their mixture, with MnBP and MMP contributing the most. Stratified analysis found that these associations were mainly observed in girls. Our mixture analysis revealed cumulative risks of oxidative DNA damage when there was co-exposure to these two kinds of EDCs. These results underscore the importance of considering the risks associated with organic UV filters and the necessity of evaluating the effects of all these pollutants, both individually and in mixtures.
[Display omitted]
•Individual organic UV filters and their mixture are associated with elevated 8-OHdG.•BP-3 and OD-PABA are the dominant contributors of the mixture effect on 8-OHdG.•Stratified analysis shows gender differences.•Mixture of organic UV filters is associated with decreased HNE-MA level.•Co-exposure elevates 8-OHdG level which exhibits cumulative risks.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.scitotenv.2023.167433</doi><tpages>1</tpages></addata></record> |
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| subjects | adiposity biomarkers China DNA damage Endocrine disruptors environment metabolites Mixture analysis oxidative stress Oxidative stress biomarkers phthalates Prospective follow-up study |
| title | Co-exposure to organic UV filters and phthalates and their associations with oxidative stress levels in children: A prospective follow-up study in China |
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