Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder

Treatment-resistant depression responds quickly to ketamine. As an -methyl-d-aspartate receptor (NMDAR) antagonist, ketamine may affect prefrontal cortex (PFC) neurons. Recent investigations reveal that the ( )-enantiomer is the most effective and least abuseable antidepressant. The Food and Drug Ad...

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Veröffentlicht in:	Journal of medicinal chemistry 2025-01, Vol.68 (2), p.944
Hauptverfasser:	Faustino Martins, Allana Cristina, Badenoch, Bretton, da Silva Gomes, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - chemistry Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Depressive Disorder - drug therapy Humans Ketamine - pharmacology Ketamine - therapeutic use Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Stereoisomerism
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