Cucurbitacin IIb mitigates concanavalin A-induced acute liver injury by suppressing M1 macrophage polarization

•Cucurbitacin IIb, extracted from Hemsleya amabilis, has anti-inflammatory activity.•CuIIb regulates M1 macrophage activation via NF-κB and MAPK signaling pathways.•It prevents concanavalin A-induced ALI by inhibiting M1 macrophage polarization.•CuIIb alleviates liver injury symptoms and has potenti...

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Veröffentlicht in:	International immunopharmacology 2025-01, Vol.147, p.113964, Article 113964
Hauptverfasser:	Liu, Zhihong, Gao, Min, Yan, Fenglian, Zhang, Hui, Wang, Lin, Zhao, Yuxuan, Zhao, Hongru, Xie, Xinzhou, Li, Chunxia, Dai, Jun, Xiong, Huabao, Zhang, Junfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	acute liver injury concanavalin A cucurbitacin IIb M1 macrophage
Online-Zugang:	Volltext
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