Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis
Purpose of Review The present investigation assesses efficacy of transcutaneous electrical nerve stimulation (TENS) on relief of cancer or chemotherapy-related pain. Patients with cancer experience a relatively high prevalence of pain that is reportedly undertreated. Therefore, this analysis is pert...
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| Veröffentlicht in: | Current pain and headache reports 2025-12, Vol.29 (1), p.5, Article 5 |
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| creator | Kaye, Alan D. Allen, Kaitlyn E. Shah, Shivam S. Smith, Summer A. Plaisance, Taylor R. Brouillette, Amy E. Despanie, Dani’elle J Payton, Tayler D. Rieger, Ross Singh, Naina Ahmadzadeh, Shahab Gennuso, Sonja Shekoohi, Sahar |
| description | Purpose of Review
The present investigation assesses efficacy of transcutaneous electrical nerve stimulation (TENS) on relief of cancer or chemotherapy-related pain. Patients with cancer experience a relatively high prevalence of pain that is reportedly undertreated. Therefore, this analysis is pertinent to determine if TENS is a useful complementary therapy considering its increase in accessibility and minimal side effect profile.
Recent Findings
A systematic search for eligible studies from PubMed, Google Scholar, Cochrane, and Embase was performed. The present investigation elucidated any significant differences between change in numeric rating scale of average and maximum pain scores between a TENS and non-TENS group. A nonsignificant difference was reported between TENS and non-TENS, with a mean difference of − 0.393 (95% CI − 1.780, 0.993;
P
= 0.578). For change in maximum pain reported, a nonsignificant difference was also found, with a mean difference of 0.128 (95% CI − 1.158, 1.414;
P
= 0.845).
Conclusion
Related to various limitations of this meta-analysis, no definitive conclusions could be concluded regarding efficacy of TENS in the treatment of cancer or chemotherapy-related pain. Additional randomized primary studies with standardized treatment protocols and pain measurements are needed for future meta-analysis and recommendations for clinical practice. |
| doi_str_mv | 10.1007/s11916-024-01337-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3151584702</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3151584702</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-ec7a3080584f4f6f0d9e137e3340b554441a1906c761022a67f56c0d9a7b305f3</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhS0EoqXwB1ggS2zYBGbi1w276urykFpAoqytue64SpU4xU4q3X-P2xSQWLCakeY7Z8Y-QrxEeIsA7l1B7NA20OoGUCnXwCNxjEbpRsEGH9_32Cit1JF4Vso1QAubDT4VR6pzRtvOHQvexdgHCgc5RXmRKZWwzJR4WorcDRzmXKeD_ML5luX3uR-XgeZ-SrJP8pwSXfHIab4TbykFzvIb9em9JHnOM8nTRMOh9OW5eBJpKPzioZ6IHx92F9tPzdnXj5-3p2dNaI2dGw6O6ulgNjrqaCNcdozKsVIa9sZorZGwAxucRWhbsi4aGypFbq_ARHUi3qy-N3n6uXCZ_diXwMOwvsgrNFjNHbQVff0Pej0tud67UrqucLZS7UqFPJWSOfqb3I-UDx7B34Xg1xB8DcHfh-Chil49WC_7kS__SH7_egXUCpQ6Slec_-7-j-0vv3WQIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3151476176</pqid></control><display><type>article</type><title>Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kaye, Alan D. ; Allen, Kaitlyn E. ; Shah, Shivam S. ; Smith, Summer A. ; Plaisance, Taylor R. ; Brouillette, Amy E. ; Despanie, Dani’elle J ; Payton, Tayler D. ; Rieger, Ross ; Singh, Naina ; Ahmadzadeh, Shahab ; Gennuso, Sonja ; Shekoohi, Sahar</creator><creatorcontrib>Kaye, Alan D. ; Allen, Kaitlyn E. ; Shah, Shivam S. ; Smith, Summer A. ; Plaisance, Taylor R. ; Brouillette, Amy E. ; Despanie, Dani’elle J ; Payton, Tayler D. ; Rieger, Ross ; Singh, Naina ; Ahmadzadeh, Shahab ; Gennuso, Sonja ; Shekoohi, Sahar</creatorcontrib><description>Purpose of Review
The present investigation assesses efficacy of transcutaneous electrical nerve stimulation (TENS) on relief of cancer or chemotherapy-related pain. Patients with cancer experience a relatively high prevalence of pain that is reportedly undertreated. Therefore, this analysis is pertinent to determine if TENS is a useful complementary therapy considering its increase in accessibility and minimal side effect profile.
Recent Findings
A systematic search for eligible studies from PubMed, Google Scholar, Cochrane, and Embase was performed. The present investigation elucidated any significant differences between change in numeric rating scale of average and maximum pain scores between a TENS and non-TENS group. A nonsignificant difference was reported between TENS and non-TENS, with a mean difference of − 0.393 (95% CI − 1.780, 0.993;
P
= 0.578). For change in maximum pain reported, a nonsignificant difference was also found, with a mean difference of 0.128 (95% CI − 1.158, 1.414;
P
= 0.845).
Conclusion
Related to various limitations of this meta-analysis, no definitive conclusions could be concluded regarding efficacy of TENS in the treatment of cancer or chemotherapy-related pain. Additional randomized primary studies with standardized treatment protocols and pain measurements are needed for future meta-analysis and recommendations for clinical practice.</description><identifier>ISSN: 1531-3433</identifier><identifier>ISSN: 1534-3081</identifier><identifier>EISSN: 1534-3081</identifier><identifier>DOI: 10.1007/s11916-024-01337-0</identifier><identifier>PMID: 39754697</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alternative Treatments for Pain Medicine (C Robinson ; Cancer Pain - therapy ; Cancer therapies ; Chemotherapy ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Neoplasms - complications ; Neoplasms - therapy ; Pain ; Pain Management - methods ; Pain Measurement - methods ; Pain Medicine ; Section Editor ; Topical Collection on Alternative Treatments for Pain Medicine ; Transcutaneous Electric Nerve Stimulation - methods ; Transcutaneous electrical nerve stimulation-TENS ; Treatment Outcome</subject><ispartof>Current pain and headache reports, 2025-12, Vol.29 (1), p.5, Article 5</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Dec 2025</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-ec7a3080584f4f6f0d9e137e3340b554441a1906c761022a67f56c0d9a7b305f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11916-024-01337-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11916-024-01337-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39754697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaye, Alan D.</creatorcontrib><creatorcontrib>Allen, Kaitlyn E.</creatorcontrib><creatorcontrib>Shah, Shivam S.</creatorcontrib><creatorcontrib>Smith, Summer A.</creatorcontrib><creatorcontrib>Plaisance, Taylor R.</creatorcontrib><creatorcontrib>Brouillette, Amy E.</creatorcontrib><creatorcontrib>Despanie, Dani’elle J</creatorcontrib><creatorcontrib>Payton, Tayler D.</creatorcontrib><creatorcontrib>Rieger, Ross</creatorcontrib><creatorcontrib>Singh, Naina</creatorcontrib><creatorcontrib>Ahmadzadeh, Shahab</creatorcontrib><creatorcontrib>Gennuso, Sonja</creatorcontrib><creatorcontrib>Shekoohi, Sahar</creatorcontrib><title>Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis</title><title>Current pain and headache reports</title><addtitle>Curr Pain Headache Rep</addtitle><addtitle>Curr Pain Headache Rep</addtitle><description>Purpose of Review
The present investigation assesses efficacy of transcutaneous electrical nerve stimulation (TENS) on relief of cancer or chemotherapy-related pain. Patients with cancer experience a relatively high prevalence of pain that is reportedly undertreated. Therefore, this analysis is pertinent to determine if TENS is a useful complementary therapy considering its increase in accessibility and minimal side effect profile.
Recent Findings
A systematic search for eligible studies from PubMed, Google Scholar, Cochrane, and Embase was performed. The present investigation elucidated any significant differences between change in numeric rating scale of average and maximum pain scores between a TENS and non-TENS group. A nonsignificant difference was reported between TENS and non-TENS, with a mean difference of − 0.393 (95% CI − 1.780, 0.993;
P
= 0.578). For change in maximum pain reported, a nonsignificant difference was also found, with a mean difference of 0.128 (95% CI − 1.158, 1.414;
P
= 0.845).
Conclusion
Related to various limitations of this meta-analysis, no definitive conclusions could be concluded regarding efficacy of TENS in the treatment of cancer or chemotherapy-related pain. Additional randomized primary studies with standardized treatment protocols and pain measurements are needed for future meta-analysis and recommendations for clinical practice.</description><subject>Alternative Treatments for Pain Medicine (C Robinson</subject><subject>Cancer Pain - therapy</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - therapy</subject><subject>Pain</subject><subject>Pain Management - methods</subject><subject>Pain Measurement - methods</subject><subject>Pain Medicine</subject><subject>Section Editor</subject><subject>Topical Collection on Alternative Treatments for Pain Medicine</subject><subject>Transcutaneous Electric Nerve Stimulation - methods</subject><subject>Transcutaneous electrical nerve stimulation-TENS</subject><subject>Treatment Outcome</subject><issn>1531-3433</issn><issn>1534-3081</issn><issn>1534-3081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhS0EoqXwB1ggS2zYBGbi1w276urykFpAoqytue64SpU4xU4q3X-P2xSQWLCakeY7Z8Y-QrxEeIsA7l1B7NA20OoGUCnXwCNxjEbpRsEGH9_32Cit1JF4Vso1QAubDT4VR6pzRtvOHQvexdgHCgc5RXmRKZWwzJR4WorcDRzmXKeD_ML5luX3uR-XgeZ-SrJP8pwSXfHIab4TbykFzvIb9em9JHnOM8nTRMOh9OW5eBJpKPzioZ6IHx92F9tPzdnXj5-3p2dNaI2dGw6O6ulgNjrqaCNcdozKsVIa9sZorZGwAxucRWhbsi4aGypFbq_ARHUi3qy-N3n6uXCZ_diXwMOwvsgrNFjNHbQVff0Pej0tud67UrqucLZS7UqFPJWSOfqb3I-UDx7B34Xg1xB8DcHfh-Chil49WC_7kS__SH7_egXUCpQ6Slec_-7-j-0vv3WQIQ</recordid><startdate>20251201</startdate><enddate>20251201</enddate><creator>Kaye, Alan D.</creator><creator>Allen, Kaitlyn E.</creator><creator>Shah, Shivam S.</creator><creator>Smith, Summer A.</creator><creator>Plaisance, Taylor R.</creator><creator>Brouillette, Amy E.</creator><creator>Despanie, Dani’elle J</creator><creator>Payton, Tayler D.</creator><creator>Rieger, Ross</creator><creator>Singh, Naina</creator><creator>Ahmadzadeh, Shahab</creator><creator>Gennuso, Sonja</creator><creator>Shekoohi, Sahar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20251201</creationdate><title>Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis</title><author>Kaye, Alan D. ; Allen, Kaitlyn E. ; Shah, Shivam S. ; Smith, Summer A. ; Plaisance, Taylor R. ; Brouillette, Amy E. ; Despanie, Dani’elle J ; Payton, Tayler D. ; Rieger, Ross ; Singh, Naina ; Ahmadzadeh, Shahab ; Gennuso, Sonja ; Shekoohi, Sahar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-ec7a3080584f4f6f0d9e137e3340b554441a1906c761022a67f56c0d9a7b305f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Alternative Treatments for Pain Medicine (C Robinson</topic><topic>Cancer Pain - therapy</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - therapy</topic><topic>Pain</topic><topic>Pain Management - methods</topic><topic>Pain Measurement - methods</topic><topic>Pain Medicine</topic><topic>Section Editor</topic><topic>Topical Collection on Alternative Treatments for Pain Medicine</topic><topic>Transcutaneous Electric Nerve Stimulation - methods</topic><topic>Transcutaneous electrical nerve stimulation-TENS</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaye, Alan D.</creatorcontrib><creatorcontrib>Allen, Kaitlyn E.</creatorcontrib><creatorcontrib>Shah, Shivam S.</creatorcontrib><creatorcontrib>Smith, Summer A.</creatorcontrib><creatorcontrib>Plaisance, Taylor R.</creatorcontrib><creatorcontrib>Brouillette, Amy E.</creatorcontrib><creatorcontrib>Despanie, Dani’elle J</creatorcontrib><creatorcontrib>Payton, Tayler D.</creatorcontrib><creatorcontrib>Rieger, Ross</creatorcontrib><creatorcontrib>Singh, Naina</creatorcontrib><creatorcontrib>Ahmadzadeh, Shahab</creatorcontrib><creatorcontrib>Gennuso, Sonja</creatorcontrib><creatorcontrib>Shekoohi, Sahar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Current pain and headache reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaye, Alan D.</au><au>Allen, Kaitlyn E.</au><au>Shah, Shivam S.</au><au>Smith, Summer A.</au><au>Plaisance, Taylor R.</au><au>Brouillette, Amy E.</au><au>Despanie, Dani’elle J</au><au>Payton, Tayler D.</au><au>Rieger, Ross</au><au>Singh, Naina</au><au>Ahmadzadeh, Shahab</au><au>Gennuso, Sonja</au><au>Shekoohi, Sahar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis</atitle><jtitle>Current pain and headache reports</jtitle><stitle>Curr Pain Headache Rep</stitle><addtitle>Curr Pain Headache Rep</addtitle><date>2025-12-01</date><risdate>2025</risdate><volume>29</volume><issue>1</issue><spage>5</spage><pages>5-</pages><artnum>5</artnum><issn>1531-3433</issn><issn>1534-3081</issn><eissn>1534-3081</eissn><abstract>Purpose of Review
The present investigation assesses efficacy of transcutaneous electrical nerve stimulation (TENS) on relief of cancer or chemotherapy-related pain. Patients with cancer experience a relatively high prevalence of pain that is reportedly undertreated. Therefore, this analysis is pertinent to determine if TENS is a useful complementary therapy considering its increase in accessibility and minimal side effect profile.
Recent Findings
A systematic search for eligible studies from PubMed, Google Scholar, Cochrane, and Embase was performed. The present investigation elucidated any significant differences between change in numeric rating scale of average and maximum pain scores between a TENS and non-TENS group. A nonsignificant difference was reported between TENS and non-TENS, with a mean difference of − 0.393 (95% CI − 1.780, 0.993;
P
= 0.578). For change in maximum pain reported, a nonsignificant difference was also found, with a mean difference of 0.128 (95% CI − 1.158, 1.414;
P
= 0.845).
Conclusion
Related to various limitations of this meta-analysis, no definitive conclusions could be concluded regarding efficacy of TENS in the treatment of cancer or chemotherapy-related pain. Additional randomized primary studies with standardized treatment protocols and pain measurements are needed for future meta-analysis and recommendations for clinical practice.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39754697</pmid><doi>10.1007/s11916-024-01337-0</doi></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alternative Treatments for Pain Medicine (C Robinson Cancer Pain - therapy Cancer therapies Chemotherapy Humans Internal Medicine Medicine Medicine & Public Health Neoplasms - complications Neoplasms - therapy Pain Pain Management - methods Pain Measurement - methods Pain Medicine Section Editor Topical Collection on Alternative Treatments for Pain Medicine Transcutaneous Electric Nerve Stimulation - methods Transcutaneous electrical nerve stimulation-TENS Treatment Outcome |
| title | Efficacy of Transcutaneous Electrical Nerve Stimulation in Management of Cancer Pain: a Meta Analysis |
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