Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system

Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is involved in EAE disease progression. We evaluated the efficacy of crisdesalazine (a novel mic...

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Veröffentlicht in:	BMC neuroscience 2025-01, Vol.26 (1), p.1-13, Article 1
Hauptverfasser:	Park, Su-Min, Oh, Yong-Hun, Lim, Ga-Hyun, An, Ju-Hyun, Lee, Jin-Hwan, Gwag, Byoung-Joo, Won, So-Jung, Seo, Kyoung-Won, Youn, Hwa-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models in research Anti-inflammation Anti-inflammatory drugs Crisdesalazine Dosage and administration Drug therapy Encephalomyelitis Experimental autoimmune encephalomyelitis Health aspects Immune system Inflammation Macrophage Microsomal prostaglandin E2 synthase-1 Multiple sclerosis Pharmacology, Experimental Physiological aspects
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