Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4

Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monitor pH changes related to their physiology and generate adaptive reactions. However, the evolutionary trajectory and structural mechanism of proton sensing by GPR4 remain unresolved. Here, we obse...

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Veröffentlicht in:	Cell 2024-12
Hauptverfasser:	Wen, Xin, Shang, Pan, Chen, Haidi, Guo, Lulu, Rong, Naikang, Jiang, Xiaoyu, Li, Xuan, Liu, Junyan, Yang, Gongming, Zhang, Jiacheng, Zhu, Kongkai, Meng, Qingbiao, He, Xuefei, Wang, Zhihai, Liu, Zili, Cheng, Haoran, Zheng, Yilin, Zhang, Bifei, Pang, Jiaojiao, Liu, Zhaoqian, Xiao, Peng, Chen, Yuguo, Liu, Lunxu, Luo, Fengming, Yu, Xiao, Yi, Fan, Zhang, Pengju, Yang, Fan, Deng, Cheng, Sun, Jin-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	cryo-EM evolution GPCR GPR4 proton sensing
Online-Zugang:	Volltext
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