Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion

Biogenesis of membrane-bound organelles involves the synthesis, remodeling, and degradation of their constituent phospholipids. How these pathways regulate organelle size remains poorly understood. Here we demonstrate that a lipid-degradation pathway inhibits expansion of the endoplasmic reticulum (...

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Veröffentlicht in:The EMBO journal 2025-01
Hauptverfasser: Lysyganicz, Pawel K, Barbosa, Antonio D, Khondker, Shoily, Stewart, Nicolas A, Carman, George M, Stansfeld, Phillip J, Dymond, Marcus K, Siniossoglou, Symeon
Format: Artikel
Sprache:eng
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