Basic Science and Pathogenesis

Calcineurin, a protein involved in functions such as synaptic plasticity and neuronal survival, plays an important role in the pathophysiology of Alzheimer's disease. This study, randomized, investigated the effects of FK506 (FK), a calcineurin inhibitor, on the behavioral, histological, and bi...

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Veröffentlicht in:	Alzheimer's & dementia 2024-12, Vol.20 Suppl 1, p.e086388
Hauptverfasser:	Santos, Sarah Tavares Araújo, Gomes, Giovanni Freitas, Rocha, Nádia Gomes, Oliveira, Antônio Carlos Pinheiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Animals Calcineurin Inhibitors - pharmacology Disease Models, Animal Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Humans Male Mice Mice, Inbred C57BL Mice, Transgenic N-Methylaspartate - pharmacology Peptide Fragments Presenilin-1 - genetics Tacrolimus - pharmacology
Online-Zugang:	Volltext
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