Basic Science and Pathogenesis

Autosomal dominant progranulin (GRN) mutations are a common genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN-related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression. We previously showed that...

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Veröffentlicht in:	Alzheimer's & dementia 2024-12, Vol.20 Suppl 1, p.e087301
Hauptverfasser:	Flagan, Taru M, Chu, Stephanie A, Häkkinen, Suvi, Zhang, Liwen, McFall, David, Heller, Carolin, Rohrer, Jonathan D, Brown, Jesse A, Lee, Alex Jihun, Fernhoff, Kristen, Pasquini, Lorenzo, Mandelli, Maria Luisa, Tempini, Maria Luisa Gorno, Yokoyama, Jennifer S, Sturm, Virginia, Appleby, Brian, Dickerson, Brad C, Domoto-Reilly, Kimiko, Foroud, Tatiana M, Geschwind, Daniel H, Ghoshal, Nupur, Graff-Radford, Neill R, Grossman, Murray, Hsiung, Ging-Yuek Robin, Huang, Eric J, Huey, Edward D, Kantarci, Kejal, Karydas, Anna M, Kaufer, Daniel, Knopman, David S, Litvan, Irene, MacKenzie, Ian R, Mendez, Mario F, Onyike, Chiadi U, Petrucelli, Leonard, Ramos, Eliana Marisa, Roberson, Erik D, Rojas, Julio C, Tartaglia, Maria Carmela, Toga, Arthur W, Weintraub, Sandra, Forsberg, Leah K, Heuer, Hilary W, Boeve, Brad F, Boxer, Adam L, Rosen, Howard J, Miller, Bruce L, Moreno, Fermin, Seeley, William W, Lee, Suzee E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atrophy - pathology Biomarkers - blood Brain - diagnostic imaging Brain - pathology Complement C1q - genetics Disease Progression Female Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - pathology Gray Matter - diagnostic imaging Gray Matter - pathology Humans Magnetic Resonance Imaging Male Middle Aged Mutation Neurofilament Proteins - blood Progranulins - genetics
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