Clinical Manifestations
A patient presented to movement disorder clinic with cognitive complaints, imbalance and prior diagnosis of NPH. The patient underwent ventriculoperitoneal shunt in the past with minimal improvement, a detailed history is suggestive of REM sleep behavioral disorder, autonomic dysfunction including o...
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| Veröffentlicht in: | Alzheimer's & dementia 2024-12, Vol.20 Suppl 3, p.e093559 |
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| container_title | Alzheimer's & dementia |
| container_volume | 20 Suppl 3 |
| creator | Elkasaby, Mohamed Hayden, Elliott Appleby, Brian |
| description | A patient presented to movement disorder clinic with cognitive complaints, imbalance and prior diagnosis of NPH. The patient underwent ventriculoperitoneal shunt in the past with minimal improvement, a detailed history is suggestive of REM sleep behavioral disorder, autonomic dysfunction including orthostatic hypotension and urinary incontinence.
Clinical evaluation was notable for bradykinesia, rigidity, truncal and cervical dystonia, shuffling steps, reduced arm swing bilaterally and pink, dusky skin of both hands.
DaTscan showed reduced uptake of dopamine transporter.
Evaluation at movement disorder clinic helps early diagnosis of neurodegenerative disorders with subtle findings which allows patients to benefit from available treatments and participation in appropriate clinical trials. |
| doi_str_mv | 10.1002/alz.093559 |
| format | Article |
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Clinical evaluation was notable for bradykinesia, rigidity, truncal and cervical dystonia, shuffling steps, reduced arm swing bilaterally and pink, dusky skin of both hands.
DaTscan showed reduced uptake of dopamine transporter.
Evaluation at movement disorder clinic helps early diagnosis of neurodegenerative disorders with subtle findings which allows patients to benefit from available treatments and participation in appropriate clinical trials.</description><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.093559</identifier><identifier>PMID: 39750096</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Female ; Humans ; Hydrocephalus, Normal Pressure - diagnosis ; Hydrocephalus, Normal Pressure - surgery ; Male ; Middle Aged ; Movement Disorders - diagnosis ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Alzheimer's & dementia, 2024-12, Vol.20 Suppl 3, p.e093559</ispartof><rights>2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39750096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elkasaby, Mohamed</creatorcontrib><creatorcontrib>Hayden, Elliott</creatorcontrib><creatorcontrib>Appleby, Brian</creatorcontrib><title>Clinical Manifestations</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>A patient presented to movement disorder clinic with cognitive complaints, imbalance and prior diagnosis of NPH. The patient underwent ventriculoperitoneal shunt in the past with minimal improvement, a detailed history is suggestive of REM sleep behavioral disorder, autonomic dysfunction including orthostatic hypotension and urinary incontinence.
Clinical evaluation was notable for bradykinesia, rigidity, truncal and cervical dystonia, shuffling steps, reduced arm swing bilaterally and pink, dusky skin of both hands.
DaTscan showed reduced uptake of dopamine transporter.
Evaluation at movement disorder clinic helps early diagnosis of neurodegenerative disorders with subtle findings which allows patients to benefit from available treatments and participation in appropriate clinical trials.</description><subject>Aged</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocephalus, Normal Pressure - diagnosis</subject><subject>Hydrocephalus, Normal Pressure - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement Disorders - diagnosis</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNjzlPxDAUhC0EYg9oaOgQJU2W5-MldomiBVZaRLN99JzYkpFzEG8K-PVEYpGoZopvZjSM3XDYcADxSPF7A0YimjO25IgiQ1GY839-wVYpfQAo0Bwv2UKaAgFMvmS3ZQxdqCnev1EXvEtHOoa-S1fswlNM7vqka3Z43h7K12z__rIrn_bZgHmeWe-xLkThBIGHRmtUghtw2nGtDJHnSti64cqisTla4N6Tth79HETQcs0efmuHsf-c5vWqDal2MVLn-ilVkiMXICWqGb07oZNtXVMNY2hp_Kr-vsgf4K9JBg</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Elkasaby, Mohamed</creator><creator>Hayden, Elliott</creator><creator>Appleby, Brian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Clinical Manifestations</title><author>Elkasaby, Mohamed ; Hayden, Elliott ; Appleby, Brian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p566-bff5c727e2a0f0d88542190e8e1849aaf142bcd14b59b65b01ffa8bf5fff55083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Dopamine Plasma Membrane Transport Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocephalus, Normal Pressure - diagnosis</topic><topic>Hydrocephalus, Normal Pressure - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement Disorders - diagnosis</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elkasaby, Mohamed</creatorcontrib><creatorcontrib>Hayden, Elliott</creatorcontrib><creatorcontrib>Appleby, Brian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elkasaby, Mohamed</au><au>Hayden, Elliott</au><au>Appleby, Brian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Manifestations</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2024-12</date><risdate>2024</risdate><volume>20 Suppl 3</volume><spage>e093559</spage><pages>e093559-</pages><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>A patient presented to movement disorder clinic with cognitive complaints, imbalance and prior diagnosis of NPH. The patient underwent ventriculoperitoneal shunt in the past with minimal improvement, a detailed history is suggestive of REM sleep behavioral disorder, autonomic dysfunction including orthostatic hypotension and urinary incontinence.
Clinical evaluation was notable for bradykinesia, rigidity, truncal and cervical dystonia, shuffling steps, reduced arm swing bilaterally and pink, dusky skin of both hands.
DaTscan showed reduced uptake of dopamine transporter.
Evaluation at movement disorder clinic helps early diagnosis of neurodegenerative disorders with subtle findings which allows patients to benefit from available treatments and participation in appropriate clinical trials.</abstract><cop>United States</cop><pmid>39750096</pmid><doi>10.1002/alz.093559</doi></addata></record> |
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| ispartof | Alzheimer's & dementia, 2024-12, Vol.20 Suppl 3, p.e093559 |
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| source | MEDLINE; Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; PubMed Central; PubMed Central Open Access |
| subjects | Aged Dopamine Plasma Membrane Transport Proteins - metabolism Female Humans Hydrocephalus, Normal Pressure - diagnosis Hydrocephalus, Normal Pressure - surgery Male Middle Aged Movement Disorders - diagnosis Tomography, Emission-Computed, Single-Photon |
| title | Clinical Manifestations |
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