Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model

: The aim of the current study was to study the therapeutic potential of chrysin against repeated intranasal amyloid-beta (Aβ)-induced interleukin-17 (IL-17) signaling in a mouse model of AD. : Male BALB/c mice were daily exposed to intranasal Aβ (10 μg/10 μL) for seven consecutive days. Chrysin was...

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Veröffentlicht in:	Food & function 2025-01, Vol.16 (2), p.731-749
Hauptverfasser:	Singh Gautam, Avtar, Panda, Ekta Swarnamayee, Balki, Sneha, Pandey, Shivam Kumar, Tiwari, Aman, Singh, Rakesh Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Anti-inflammatory agents Brain Brain - drug effects Brain - metabolism Carboxymethyl cellulose Cellulose Cytokines Disease Models, Animal Exposure Flavonoids - administration & dosage Flavonoids - pharmacology Humans Immunohistochemistry Inflammation Interleukin 17 Interleukin-17 - metabolism Interleukins Male Memory Methylcellulose Mice Mice, Inbred BALB C Neurodegenerative diseases Object recognition Oral administration Pattern recognition Peptide Fragments Signal Transduction - drug effects Spatial discrimination learning Spatial memory TRAF6 protein β-Amyloid
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