Sensation is dispensable for the maturation of the vestibulo-ocular reflex
Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval z...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2025-01, Vol.387 (6729), p.85-90 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Leary, Paige Bellegarda, Celine Quainoo, Cheryl Goldblatt, Dena Rosti, Başak Schoppik, David |
| description | Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior. |
| doi_str_mv | 10.1126/science.adr9982 |
| format | Article |
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Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. 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| ispartof | Science (American Association for the Advancement of Science), 2025-01, Vol.387 (6729), p.85-90 |
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| subjects | Animals Eye movements Eye Movements - physiology Feedback, Sensory Head movement Larva - physiology Larvae Maturation Motor neurons Motor Neurons - physiology Muscles Neuromuscular Junction - physiology Neuromuscular junctions Neurons Oculomotor Muscles - innervation Oculomotor Muscles - physiology Reflex, Vestibulo-Ocular - physiology Sensory feedback Sensory neurons Stabilization Vestibular system Vestibulo-ocular reflex Zebrafish Zebrafish - physiology |
| title | Sensation is dispensable for the maturation of the vestibulo-ocular reflex |
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