Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with a very poor prognosis. It is characterized by a dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, the combination of CT with hyperthermi...

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Veröffentlicht in:	ACS applied materials & interfaces 2025-01, Vol.17 (2), p.2924-2939
Hauptverfasser:	Díaz-Riascos, Zamira V., Llaguno-Munive, Monserrat, Lafuente-Gómez, Nuria, Luengo, Yurena, Holmes, Sarah, Volatron, Jeanne, Ibarrola, Oihane, Mancilla, Sandra, Sarno, Francesca, Aguirre, José Javier, Razafindrakoto, Sarah, Southern, Paul, Terán, Francisco J., Keogh, Anna, Salas, Gorka, Prina-Mello, Adriele, Lacal, Juan Carlos, del Pozo, Angel, Pankhurst, Quentin A., Hidalgo, Manuel, Gazeau, Florence, Somoza, Álvaro, Schwartz, Simó, Abasolo, Ibane
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - chemistry Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and Medical Applications of Materials and Interfaces Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Cell Line, Tumor Cell Survival - drug effects Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - pharmacology Deoxycytidine - therapeutic use Gemcitabine Humans Hyperthermia, Induced Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use Mice Mice, Nude Paclitaxel - chemistry Paclitaxel - pharmacology Paclitaxel - therapeutic use Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy
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