Controlling intracellular protein delivery, tumor colonization and tissue distribution using the master regulator flhDC in a clinically relevant ΔsseJ Salmonella strain

Effectively targeting intracellular pathways in cancers requires a system that specifically delivers to tumors and internalizes into cancer cells. To achieve this goal, we developed intracellular-delivering (ID) Salmonella with controllable expression of flhDC to regulate flagella production and cel...

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Veröffentlicht in:	Molecular therapy 2024-12
Hauptverfasser:	Raman, Vishnu, Hall, Christopher L., Wetherby, Victoria E., Witney, Samantha A., Van Dessel, Nele, Forbes, Neil S.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacterial cancer therapy intracellular delivery Salmonella synthetic biology targeted cancer therapy
Online-Zugang:	Volltext
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