Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice

Lymphatic muscle cells (LMCs) within the wall of collecting lymphatic vessels exhibit tonic and autonomous phasic contractions, which drive active lymph transport to maintain tissue-fluid homeostasis and support immune surveillance. Damage to LMCs disrupts lymphatic function and is related to variou...

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Veröffentlicht in:	Developmental cell 2024-12
Hauptverfasser:	Lei, Pin-Ji, Ruscic, Katarina J, Roh, Kangsan, Rajotte, Johanna J, O'Melia, Meghan J, Bouta, Echoe M, Marquez, Marla, Pereira, Ethel R, Kumar, Ashwin S, Razavi, Mohammad S, Zhou, Hengbo, Menzel, Lutz, Huang, Liqing, Kumra, Heena, Duquette, Mark, Huang, Peigen, Baish, James W, Munn, Lance L, Kurpios, Natasza A, Ubellacker, Jessalyn M, Padera, Timothy P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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