Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
[Display omitted] Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplin...
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| Veröffentlicht in: | International journal of pharmaceutics 2024-12, Vol.670, p.125135, Article 125135 |
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| container_title | International journal of pharmaceutics |
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| creator | Morsy, Hadeer M. Zaky, Mohamed Y. Yassin, Nour Y.S. Khalifa, Ashraf Y.Z. |
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Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system. |
| doi_str_mv | 10.1016/j.ijpharm.2024.125135 |
| format | Article |
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Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.</description><identifier>ISSN: 0378-5173</identifier><identifier>ISSN: 1873-3476</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2024.125135</identifier><identifier>PMID: 39732216</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antioxidant ; Bioavailability enhancement ; Biomedical applications ; Flavonoid therapeutics ; Nanoparticle-based flavonoid ; Polyphenolic molecules</subject><ispartof>International journal of pharmaceutics, 2024-12, Vol.670, p.125135, Article 125135</ispartof><rights>2024</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1586-58797a9477e569cfb8795706a913d07819460a744869670107d8e30e07d665a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517324013693$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39732216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morsy, Hadeer M.</creatorcontrib><creatorcontrib>Zaky, Mohamed Y.</creatorcontrib><creatorcontrib>Yassin, Nour Y.S.</creatorcontrib><creatorcontrib>Khalifa, Ashraf Y.Z.</creatorcontrib><title>Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.</description><subject>Antioxidant</subject><subject>Bioavailability enhancement</subject><subject>Biomedical applications</subject><subject>Flavonoid therapeutics</subject><subject>Nanoparticle-based flavonoid</subject><subject>Polyphenolic molecules</subject><issn>0378-5173</issn><issn>1873-3476</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFUcuOEzEQtBCIzS58AshHDplgj2f84ILQigWkFXCAs9WxO8TRjD3YMxF8Ez-JQwJXTtV2V1fbVYQ842zDGZcvD5twmPaQx03L2m7D256L_gFZca1EIzolH5IVE0o3PVfiilyXcmCMyZaLx-RKGCXalssV-fURYpogz8EN2GyhoKe7AY4ppuDpvMcMEy61W17RzyFFxBziN7oNaUQfHAwUpmmoxVybhYZIIdbyR_AVy5o6iA4znTPCPGKcTzfZh3SE4pYBMt0jDPN-TSMuOU05zehOUuuq46lLZUT3Zz8M5Ql5tKuATy94Q77evf1y-765__Tuw-2b-8bxXsum18ooMJ1S2Evjdtt67hWTYLjwTGluOslAdZ2WRirGmfIaBcOKUvbQihvy4qxbn_N9wTLbMRSHwwAR01Ks4J3RuvpnKrU_U11OpWTc2SmHEfJPy5k95WQP9pKTPeVkzznVueeXFcu2Gvlv6m8wlfD6TMD60WPAbIsLWL30IVeHrE_hPyt-A9efqhE</recordid><startdate>20241226</startdate><enddate>20241226</enddate><creator>Morsy, Hadeer M.</creator><creator>Zaky, Mohamed Y.</creator><creator>Yassin, Nour Y.S.</creator><creator>Khalifa, Ashraf Y.Z.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241226</creationdate><title>Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals</title><author>Morsy, Hadeer M. ; Zaky, Mohamed Y. ; Yassin, Nour Y.S. ; Khalifa, Ashraf Y.Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1586-58797a9477e569cfb8795706a913d07819460a744869670107d8e30e07d665a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antioxidant</topic><topic>Bioavailability enhancement</topic><topic>Biomedical applications</topic><topic>Flavonoid therapeutics</topic><topic>Nanoparticle-based flavonoid</topic><topic>Polyphenolic molecules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morsy, Hadeer M.</creatorcontrib><creatorcontrib>Zaky, Mohamed Y.</creatorcontrib><creatorcontrib>Yassin, Nour Y.S.</creatorcontrib><creatorcontrib>Khalifa, Ashraf Y.Z.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morsy, Hadeer M.</au><au>Zaky, Mohamed Y.</au><au>Yassin, Nour Y.S.</au><au>Khalifa, Ashraf Y.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2024-12-26</date><risdate>2024</risdate><volume>670</volume><spage>125135</spage><pages>125135-</pages><artnum>125135</artnum><issn>0378-5173</issn><issn>1873-3476</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability. Moreover, this review illustrated the pioneering biomedical applications of nanoparticle-based flavonoid therapeutics, as well as safety and toxicity considerations of using a flavonoid nanoparticle delivery system.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39732216</pmid><doi>10.1016/j.ijpharm.2024.125135</doi></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Antioxidant Bioavailability enhancement Biomedical applications Flavonoid therapeutics Nanoparticle-based flavonoid Polyphenolic molecules |
| title | Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals |
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