Design, synthesis and biological evaluation of camptothecin analogue FL118 as a payload for antibody-drug conjugates in targeted cancer therapy

[Display omitted] •FL118, a potent camptothecin derivative, enhances ADC anti-tumor activity and demonstrates efficacy in Kadcyla®-resistant cell lines.•FL118-derived ADCs showed potent in vitro cytotoxicity in various cancer cell lines and achieved significant TGI in Trop2/HER2 xenograft models.•Sa...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2025-04, Vol.118, p.130085, Article 130085
Hauptverfasser:	Mathi, Gangadhar Rao, Lee, Byeong Sung, Chun, Younghwa, Shin, Seunggun, Kweon, Sohui, Go, Areum, Jung, Jin Kyo, Lee, Jin Soo, Cho, Hyun Yong, Jung, Doo Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody-drug conjugates Anticancer drug Dual-MoA FL118 Topoisomerase I inhibitor
Online-Zugang:	Volltext
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