Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma

Systemic bile acid homeostasis plays an important role in human health. In this study, a physiologically based kinetic (PBK) model that includes microbial bile acid deconjugation and intestinal bile acid reuptake via the apical sodium-dependent bile acid transporter (ASBT) was applied to predict the...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Archives of toxicology 2024-12
Hauptverfasser:	Zhang, Nina, Rietjens, Ivonne M C M, de Bruijn, Véronique M P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!