Mechanistic insights into Quetiapine’s Protective effects on cognitive function and synaptic plasticity in epileptic rats

•Quetiapine improved cognitive function in epileptic rats.•Quetiapine suppressed the expression of MMP-9 in the hippocampus.•Quetiapine activated the CREB/BDNF pathway in the hippocampus.•Quetiapine enhanced synaptic plasticity of neurons in epileptic rats. The study aimed to examine the effects of...

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Veröffentlicht in:	Brain research 2025-03, Vol.1850, p.149426, Article 149426
Hauptverfasser:	Lan, Yanping, Li, Ao, Ding, Chenzhe, Xia, Jianxue, Zhang, Xuebing, Luo, Dongyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Brain-Derived Neurotrophic Factor - metabolism Cognition - drug effects CREB/BDNF signaling pathway Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Hippocampus - drug effects Hippocampus - metabolism Male Matrix Metalloproteinase 9 - metabolism Metallomatrix proteinase-9 Neuronal Plasticity - drug effects Neuroprotective Agents - pharmacology Pilocarpine Quetiapine Quetiapine Fumarate - pharmacology Rats Rats, Sprague-Dawley Signal Transduction - drug effects Synaptic plasticity
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