Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors

[Display omitted] •Individual water-soluble fullerene derivatives were shown to inhibit SARS-CoV-2.•High selectivity indexes up to 214 were achieved for leading compounds.•Time-of-addition test revealed spike protein and main protease as probable targets. Herein, we present the first experimental st...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic chemistry 2025-01, Vol.154, p.108097, Article 108097
Hauptverfasser:	Kraevaya, Olga A., Bolshakova, Valeriya S., Slita, Alexander V., Esaulkova, Iana L., Zhilenkov, Alexander V., Mikhalsky, Mikhail G., Sinegubova, Ekaterina O., Voronov, Ilya I., Peregudov, Alexander S., Shestakov, Alexander F., Zarubaev, Vladimir V., Troshin, Pavel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity Fullerene derivatives Mechanism SARS-CoV-2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!