Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted ‘SWATH’ Mass Spectrometry

ABSTRACT Aim To discover new salivary biomarkers to diagnose periodontitis and evaluate the impact of age and smoking on predictive capacity. Material and Methods Saliva samples were collected from 44 healthy periodontal individuals and 41 with periodontitis. Samples were analysed by sequential wind...

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Veröffentlicht in:	Journal of clinical periodontology 2025-02, Vol.52 (2), p.199-214
Hauptverfasser:	Blanco‐Pintos, T., Regueira‐Iglesias, A., Relvas, M., Alonso‐Sampedro, M., Bravo, S. B., Balsa‐Castro, C., Tomás, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adult Age Factors Aged Biomarkers Biomarkers - analysis Case-Control Studies Cytoskeleton Defensins Diagnosis, Epidemiology and Associated Co‐morbidities diagnostic accuracy Female Gum disease Humans Keratin Leukocytes (neutrophilic) Lysozyme Male Mass Spectrometry - methods Mass spectroscopy Middle Aged molecular biomarkers Molecular modelling Muramidase - analysis Original Periodontitis Periodontitis - diagnosis Periodontitis - metabolism Proenzymes Profilin Proteins proteomics Saliva Saliva - chemistry Salivary Proteins and Peptides - analysis Sensitivity and Specificity Smoking SWATH‐MS Tropomyosin Ubiquitin
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