Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI
Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study ai...
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| creator | Huang, Guocheng Albers, Patrick Mookerji, Nikhile Pfanner, Tyler Hui, Amaris Mittal, Rohan Broomfield, Stacey Dean, Lucas St. Martin, Blair Jacobsen, Niels-Erik Evans, Howard Gao, Yuan Hung, Ryan Abele, Jonathan Dromparis, Peter Lima, Joema Felipe Bismar, Tarek A. Michelakis, Evangelos Sutendra, Gopinath Wuest, Frank Tu, Wendy Adam, Benjamin A. Fung, Christopher Ghosh, Sunita Tamm, Alexander Kinnaird, Adam |
| description | Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.PURPOSEFluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.METHODS134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p |
| doi_str_mv | 10.1007/s00259-024-07021-0 |
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This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.PURPOSEFluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.METHODS134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).RESULTS286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.CONCLUSION18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.]]></description><identifier>ISSN: 1619-7070</identifier><identifier>ISSN: 1619-7089</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-024-07021-0</identifier><language>eng</language><ispartof>European journal of nuclear medicine and molecular imaging, 2024-12</ispartof><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c763-5d1566ff215843da2b23ff70c64de407dae2003cd19004da86a1531ec93ee92b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Huang, Guocheng</creatorcontrib><creatorcontrib>Albers, Patrick</creatorcontrib><creatorcontrib>Mookerji, Nikhile</creatorcontrib><creatorcontrib>Pfanner, Tyler</creatorcontrib><creatorcontrib>Hui, Amaris</creatorcontrib><creatorcontrib>Mittal, Rohan</creatorcontrib><creatorcontrib>Broomfield, Stacey</creatorcontrib><creatorcontrib>Dean, Lucas</creatorcontrib><creatorcontrib>St. Martin, Blair</creatorcontrib><creatorcontrib>Jacobsen, Niels-Erik</creatorcontrib><creatorcontrib>Evans, Howard</creatorcontrib><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Hung, Ryan</creatorcontrib><creatorcontrib>Abele, Jonathan</creatorcontrib><creatorcontrib>Dromparis, Peter</creatorcontrib><creatorcontrib>Lima, Joema Felipe</creatorcontrib><creatorcontrib>Bismar, Tarek A.</creatorcontrib><creatorcontrib>Michelakis, Evangelos</creatorcontrib><creatorcontrib>Sutendra, Gopinath</creatorcontrib><creatorcontrib>Wuest, Frank</creatorcontrib><creatorcontrib>Tu, Wendy</creatorcontrib><creatorcontrib>Adam, Benjamin A.</creatorcontrib><creatorcontrib>Fung, Christopher</creatorcontrib><creatorcontrib>Ghosh, Sunita</creatorcontrib><creatorcontrib>Tamm, Alexander</creatorcontrib><creatorcontrib>Kinnaird, Adam</creatorcontrib><creatorcontrib>The Next Generation Trial Investigators</creatorcontrib><title>Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI</title><title>European journal of nuclear medicine and molecular imaging</title><description><![CDATA[Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.PURPOSEFluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.METHODS134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).RESULTS286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.CONCLUSION18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.]]></description><issn>1619-7070</issn><issn>1619-7089</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EEqXwBzj5yMV0beflY1W1UKkVFeRuuckGjPIodlIJ7vxvXII4ze5qtJpvCLnlcM8B0pkHELFiICIGKQjO4IxMeMIVSyFT5_9zCpfkyvt3AJ6JTE3Id_7mEFlpG2y97VpTU38wvQ1ad4Wp7VdYupaatqTHrh4apOh724zXrqIH1_ne9Ej7oemcp4O37Svl2YrtXrZzdkpHd8t8tsjpEZ0fPG2GurcH40yDvbMF3T6vr8lFZWqPN386JflqmS8e2ebpYb2Yb1iRJpLFJY-TpKoEj7NIlkbshayqFIokKjGCtDQoAGRRcgUQlSZLDI8lx0JJRCX2ckruxrch9McQOHRjfYF1bVrsBq8lj1QcyUjJYBWjtQh83mGlDy5Qu0_NQZ-g9Fi5DpXr38o1yB9_33Tg</recordid><startdate>20241227</startdate><enddate>20241227</enddate><creator>Huang, Guocheng</creator><creator>Albers, Patrick</creator><creator>Mookerji, Nikhile</creator><creator>Pfanner, Tyler</creator><creator>Hui, Amaris</creator><creator>Mittal, Rohan</creator><creator>Broomfield, Stacey</creator><creator>Dean, Lucas</creator><creator>St. Martin, Blair</creator><creator>Jacobsen, Niels-Erik</creator><creator>Evans, Howard</creator><creator>Gao, Yuan</creator><creator>Hung, Ryan</creator><creator>Abele, Jonathan</creator><creator>Dromparis, Peter</creator><creator>Lima, Joema Felipe</creator><creator>Bismar, Tarek A.</creator><creator>Michelakis, Evangelos</creator><creator>Sutendra, Gopinath</creator><creator>Wuest, Frank</creator><creator>Tu, Wendy</creator><creator>Adam, Benjamin A.</creator><creator>Fung, Christopher</creator><creator>Ghosh, Sunita</creator><creator>Tamm, Alexander</creator><creator>Kinnaird, Adam</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241227</creationdate><title>Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI</title><author>Huang, Guocheng ; Albers, Patrick ; Mookerji, Nikhile ; Pfanner, Tyler ; Hui, Amaris ; Mittal, Rohan ; Broomfield, Stacey ; Dean, Lucas ; St. Martin, Blair ; Jacobsen, Niels-Erik ; Evans, Howard ; Gao, Yuan ; Hung, Ryan ; Abele, Jonathan ; Dromparis, Peter ; Lima, Joema Felipe ; Bismar, Tarek A. ; Michelakis, Evangelos ; Sutendra, Gopinath ; Wuest, Frank ; Tu, Wendy ; Adam, Benjamin A. ; Fung, Christopher ; Ghosh, Sunita ; Tamm, Alexander ; Kinnaird, Adam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c763-5d1566ff215843da2b23ff70c64de407dae2003cd19004da86a1531ec93ee92b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Guocheng</creatorcontrib><creatorcontrib>Albers, Patrick</creatorcontrib><creatorcontrib>Mookerji, Nikhile</creatorcontrib><creatorcontrib>Pfanner, Tyler</creatorcontrib><creatorcontrib>Hui, Amaris</creatorcontrib><creatorcontrib>Mittal, Rohan</creatorcontrib><creatorcontrib>Broomfield, Stacey</creatorcontrib><creatorcontrib>Dean, Lucas</creatorcontrib><creatorcontrib>St. Martin, Blair</creatorcontrib><creatorcontrib>Jacobsen, Niels-Erik</creatorcontrib><creatorcontrib>Evans, Howard</creatorcontrib><creatorcontrib>Gao, Yuan</creatorcontrib><creatorcontrib>Hung, Ryan</creatorcontrib><creatorcontrib>Abele, Jonathan</creatorcontrib><creatorcontrib>Dromparis, Peter</creatorcontrib><creatorcontrib>Lima, Joema Felipe</creatorcontrib><creatorcontrib>Bismar, Tarek A.</creatorcontrib><creatorcontrib>Michelakis, Evangelos</creatorcontrib><creatorcontrib>Sutendra, Gopinath</creatorcontrib><creatorcontrib>Wuest, Frank</creatorcontrib><creatorcontrib>Tu, Wendy</creatorcontrib><creatorcontrib>Adam, Benjamin A.</creatorcontrib><creatorcontrib>Fung, Christopher</creatorcontrib><creatorcontrib>Ghosh, Sunita</creatorcontrib><creatorcontrib>Tamm, Alexander</creatorcontrib><creatorcontrib>Kinnaird, Adam</creatorcontrib><creatorcontrib>The Next Generation Trial Investigators</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Guocheng</au><au>Albers, Patrick</au><au>Mookerji, Nikhile</au><au>Pfanner, Tyler</au><au>Hui, Amaris</au><au>Mittal, Rohan</au><au>Broomfield, Stacey</au><au>Dean, Lucas</au><au>St. Martin, Blair</au><au>Jacobsen, Niels-Erik</au><au>Evans, Howard</au><au>Gao, Yuan</au><au>Hung, Ryan</au><au>Abele, Jonathan</au><au>Dromparis, Peter</au><au>Lima, Joema Felipe</au><au>Bismar, Tarek A.</au><au>Michelakis, Evangelos</au><au>Sutendra, Gopinath</au><au>Wuest, Frank</au><au>Tu, Wendy</au><au>Adam, Benjamin A.</au><au>Fung, Christopher</au><au>Ghosh, Sunita</au><au>Tamm, Alexander</au><au>Kinnaird, Adam</au><aucorp>The Next Generation Trial Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><date>2024-12-27</date><risdate>2024</risdate><issn>1619-7070</issn><issn>1619-7089</issn><eissn>1619-7089</eissn><abstract><![CDATA[Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.PURPOSEFluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (18F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.METHODS134 participants underwent 18F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760). MRI, 18F-PSMA-1007 PET/CT, and final pathology were independently assessed by blinded radiologists, nuclear medicine physicians, and pathologists, respectively. Individual tumor nodules were measured in three dimensions and cognitively registered to 38 segment prostate diagrams as per PI-RADSv2.1. Correct spatial localization was compared using McNemar test and estimation of tumor volumes were compared using linear regression and partial F-test.286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).RESULTS286 tumor nodules were identified by final histopathology. 18F-PSMA-1007 PET/CT was superior to MRI for correct localization (186 [65.0%] vs 134 [46.9%], p < 0.001) and tumor volume estimation (R2 = 0.545 vs 0.431, p < 0.001). Larger tumors and higher Gleason Grade Group (GGG) were associated with correct localization by 18F-PSMA-1007 PET/CT (OR = 2.05, p < 0.001 for tumor volume and OR = 4.92, p < 0.01 for ≥ GGG3) and MRI (OR = 1.81, p < 0.001 for tumor volume and OR = 11.67, p < 0.001 for ≥ GGG3).18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.CONCLUSION18F-PSMA-1007 PET/CT outperforms MRI for determination of three-dimensional spatial localization and volume of prostate tumors. These findings support the use of 18F-PSMA-1007 PET/CT prior to definitive treatment of localized prostate cancers.]]></abstract><doi>10.1007/s00259-024-07021-0</doi></addata></record> |
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| title | Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI |
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