National outbreak of Shiga toxin-producing Escherichia coli O145:H28 associated with pre-packed sandwiches, United Kingdom, May–June 2024
Shiga toxin-producing Escherichia coli (STEC) is a group of bacteria that causes gastrointestinal illness and occasionally causes large foodborne outbreaks. It represents a major public health concern due to its ability to cause severe illness which can sometimes be fatal. This study was undertaken...
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| Veröffentlicht in: | Epidemiology and infection 2024-12, Vol.152, p.e179, Article e179 |
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| creator | Quinn, Orlagh Yanshi King, Grace Hoban, Ann Sawyer, Clare Douglas, Amy Painset, Anaïs Charlett, Andre Nelson, Andrew Rees, Carys Byers, Chloe Williams, Christopher Brown, Colin Mohan, Kitty Brown, Claire Jenkins, Claire Neill, Claire Leckenby, Genna Larkin, Lesley Allison, Lesley Olufon, Oluwakemi Nickbakhsh, Sema Mannes, Trish Inns, Thomas Balasegaram, Sooria |
| description | Shiga toxin-producing Escherichia coli (STEC) is a group of bacteria that causes gastrointestinal illness and occasionally causes large foodborne outbreaks. It represents a major public health concern due to its ability to cause severe illness which can sometimes be fatal. This study was undertaken as part of a rapid investigation into a national foodborne outbreak of STEC O145. On 22 May 2024, United Kingdom (UK) public health agencies and laboratories identified an increase in stool specimens submissions and patients testing positive for Shiga toxin-producing E. coli (STEC). Whole genome sequencing (WGS) identified serotype O145:H28 stx2a/eae belonging to the same five single nucleotide polymorphism (SNP) single linkage cluster as the causative agent. By 3 July 2024, 288 cases had been linked to the cluster. Most cases were adults (87%) and females (57%), 49% were hospitalized with a further 10% attending emergency care. Descriptive epidemiology and analytical studies were conducted which identified consumption of nationally distributed pre-packed sandwiches as a common food exposure. The implicated food business operators voluntarily recalled ready-to-eat sandwiches and wraps containing lettuce on 14 June 2024. |
| doi_str_mv | 10.1017/S0950268824001729 |
| format | Article |
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It represents a major public health concern due to its ability to cause severe illness which can sometimes be fatal. This study was undertaken as part of a rapid investigation into a national foodborne outbreak of STEC O145. On 22 May 2024, United Kingdom (UK) public health agencies and laboratories identified an increase in stool specimens submissions and patients testing positive for Shiga toxin-producing E. coli (STEC). Whole genome sequencing (WGS) identified serotype O145:H28 stx2a/eae belonging to the same five single nucleotide polymorphism (SNP) single linkage cluster as the causative agent. By 3 July 2024, 288 cases had been linked to the cluster. Most cases were adults (87%) and females (57%), 49% were hospitalized with a further 10% attending emergency care. Descriptive epidemiology and analytical studies were conducted which identified consumption of nationally distributed pre-packed sandwiches as a common food exposure. The implicated food business operators voluntarily recalled ready-to-eat sandwiches and wraps containing lettuce on 14 June 2024.</description><identifier>ISSN: 0950-2688</identifier><identifier>ISSN: 1469-4409</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268824001729</identifier><identifier>PMID: 39725659</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Clusters ; Coliforms ; Diarrhea ; Disease Outbreaks ; E coli ; Emergency medical care ; Emergency medical services ; Epidemics ; Epidemiology ; Escherichia coli ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Female ; Females ; Food ; Food chains ; Food consumption ; Food contamination & poisoning ; Food Microbiology ; Foodborne diseases ; Foodborne Diseases - epidemiology ; Foodborne Diseases - microbiology ; From the Field ; Gene sequencing ; Humans ; Hypotheses ; Illnesses ; Infant ; Laboratories ; Male ; Middle Aged ; Nucleotides ; Outbreaks ; Packaged goods ; Polymorphism ; Public health ; Questionnaires ; Regression analysis ; Salmonella ; Sandwiches ; Shiga toxin ; Shiga-Toxigenic Escherichia coli - classification ; Shiga-Toxigenic Escherichia coli - genetics ; Shiga-Toxigenic Escherichia coli - isolation & purification ; Single-nucleotide polymorphism ; Toxins ; United Kingdom - epidemiology ; Whole Genome Sequencing ; Young Adult</subject><ispartof>Epidemiology and infection, 2024-12, Vol.152, p.e179, Article e179</ispartof><rights>The Author(s), 2024. Published by Cambridge University Press</rights><rights>The Author(s), 2024. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. (the “License”). 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Infect</addtitle><description>Shiga toxin-producing Escherichia coli (STEC) is a group of bacteria that causes gastrointestinal illness and occasionally causes large foodborne outbreaks. It represents a major public health concern due to its ability to cause severe illness which can sometimes be fatal. This study was undertaken as part of a rapid investigation into a national foodborne outbreak of STEC O145. On 22 May 2024, United Kingdom (UK) public health agencies and laboratories identified an increase in stool specimens submissions and patients testing positive for Shiga toxin-producing E. coli (STEC). Whole genome sequencing (WGS) identified serotype O145:H28 stx2a/eae belonging to the same five single nucleotide polymorphism (SNP) single linkage cluster as the causative agent. By 3 July 2024, 288 cases had been linked to the cluster. Most cases were adults (87%) and females (57%), 49% were hospitalized with a further 10% attending emergency care. Descriptive epidemiology and analytical studies were conducted which identified consumption of nationally distributed pre-packed sandwiches as a common food exposure. The implicated food business operators voluntarily recalled ready-to-eat sandwiches and wraps containing lettuce on 14 June 2024.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clusters</subject><subject>Coliforms</subject><subject>Diarrhea</subject><subject>Disease Outbreaks</subject><subject>E coli</subject><subject>Emergency medical care</subject><subject>Emergency medical services</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Female</subject><subject>Females</subject><subject>Food</subject><subject>Food chains</subject><subject>Food consumption</subject><subject>Food contamination & poisoning</subject><subject>Food 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| fulltext | fulltext |
| identifier | ISSN: 0950-2688 |
| ispartof | Epidemiology and infection, 2024-12, Vol.152, p.e179, Article e179 |
| issn | 0950-2688 1469-4409 1469-4409 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3149541978 |
| source | MEDLINE; Cambridge Journals Open Access; DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Adolescent Adult Age Aged Aged, 80 and over Child Child, Preschool Clusters Coliforms Diarrhea Disease Outbreaks E coli Emergency medical care Emergency medical services Epidemics Epidemiology Escherichia coli Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Female Females Food Food chains Food consumption Food contamination & poisoning Food Microbiology Foodborne diseases Foodborne Diseases - epidemiology Foodborne Diseases - microbiology From the Field Gene sequencing Humans Hypotheses Illnesses Infant Laboratories Male Middle Aged Nucleotides Outbreaks Packaged goods Polymorphism Public health Questionnaires Regression analysis Salmonella Sandwiches Shiga toxin Shiga-Toxigenic Escherichia coli - classification Shiga-Toxigenic Escherichia coli - genetics Shiga-Toxigenic Escherichia coli - isolation & purification Single-nucleotide polymorphism Toxins United Kingdom - epidemiology Whole Genome Sequencing Young Adult |
| title | National outbreak of Shiga toxin-producing Escherichia coli O145:H28 associated with pre-packed sandwiches, United Kingdom, May–June 2024 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T15%3A38%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=National%20outbreak%20of%20Shiga%20toxin-producing%20Escherichia%20coli%20O145:H28%20associated%20with%20pre-packed%20sandwiches,%20United%20Kingdom,%20May%E2%80%93June%202024&rft.jtitle=Epidemiology%20and%20infection&rft.au=Quinn,%20Orlagh&rft.date=2024-12-27&rft.volume=152&rft.spage=e179&rft.pages=e179-&rft.artnum=e179&rft.issn=0950-2688&rft.eissn=1469-4409&rft_id=info:doi/10.1017/S0950268824001729&rft_dat=%3Cproquest_cross%3E3149297454%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3149297454&rft_id=info:pmid/39725659&rft_cupid=10_1017_S0950268824001729&rfr_iscdi=true |