Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

Despite the crucial role of synaptic connections and neural activity in the development and organization of cortical circuits, the mechanisms underlying the formation of functional synaptic connections in the developing human cerebral cortex remain unclear. We investigated the development of α-amino...

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Veröffentlicht in:	Neuroscience research 2024-12
Hauptverfasser:	Nishimura, Masatoshi, Kodera, Tomoki, Adachi, Shota, Sato, Akinori Y., Takeuchi, Ryosuke F., Nonaka, Hiroshi, Hamachi, Itaru, Osakada, Fumitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	functional imaging glutamate receptor glutamatergic synapse human brain neural circuit neural organoid unsilencing viral vector
Online-Zugang:	Volltext
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