High expression of SLC2A1 inhibits ferroptosis and promotes proliferation and invasion of lung adenocarcinoma cells
To examine how the glucose transporter SLC2A1 influences the proliferation and migration of lung adenocarcinoma (LUAD) and explore the underlying molecular mechanisms. We examined the differential expression of SLC2A1 between normal and LUAD tissues in the TCGA database and its prognostic implicatio...
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| Veröffentlicht in: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024-12, Vol.44 (12), p.2404 |
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| container_title | Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
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| creator | Kuang, Hong Cai, Wenhan Liu, Yiming Wen, Jiaxin Tian, Shuo Xue, Zhiqiang |
| description | To examine how the glucose transporter SLC2A1 influences the proliferation and migration of lung adenocarcinoma (LUAD) and explore the underlying molecular mechanisms.
We examined the differential expression of SLC2A1 between normal and LUAD tissues in the TCGA database and its prognostic implications. Immunohistochemistry was used to detect SLC2A1 protein levels in clinical samples of LUAD and adjacent tissues, and the association of SLC2A1 expression levels with clinicopathological features of the patients was analyzed. In PC9 cells with stable SLC2A1 overexpression or knockdown, the effects of SLC2A1 expression level on cell proliferation and migration were assessed using CCK-8 and Transwell assays, and the changes in expressions of ferroptosis- and autophagy-related proteins were measured; the occurrence of ferroptosis was confirmed using ROS and Fe
fluorescence staining.
SLC2A1 expression was significantly higher in LUAD tumor tissues than in normal lung tissues ( |
| doi_str_mv | 10.12122/j.issn.1673-4254.2024.12.17 |
| format | Article |
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We examined the differential expression of SLC2A1 between normal and LUAD tissues in the TCGA database and its prognostic implications. Immunohistochemistry was used to detect SLC2A1 protein levels in clinical samples of LUAD and adjacent tissues, and the association of SLC2A1 expression levels with clinicopathological features of the patients was analyzed. In PC9 cells with stable SLC2A1 overexpression or knockdown, the effects of SLC2A1 expression level on cell proliferation and migration were assessed using CCK-8 and Transwell assays, and the changes in expressions of ferroptosis- and autophagy-related proteins were measured; the occurrence of ferroptosis was confirmed using ROS and Fe
fluorescence staining.
SLC2A1 expression was significantly higher in LUAD tumor tissues than in normal lung tissues (
<0.05) and was associated with worse pat</description><identifier>ISSN: 1673-4254</identifier><identifier>DOI: 10.12122/j.issn.1673-4254.2024.12.17</identifier><identifier>PMID: 39725630</identifier><language>chi</language><publisher>China</publisher><subject>Adenocarcinoma of Lung - genetics ; Adenocarcinoma of Lung - metabolism ; Adenocarcinoma of Lung - pathology ; Autophagy ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Ferroptosis - genetics ; Glucose Transporter Type 1 - genetics ; Glucose Transporter Type 1 - metabolism ; Humans ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Neoplasm Invasiveness ; Prognosis</subject><ispartof>Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024-12, Vol.44 (12), p.2404</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39725630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuang, Hong</creatorcontrib><creatorcontrib>Cai, Wenhan</creatorcontrib><creatorcontrib>Liu, Yiming</creatorcontrib><creatorcontrib>Wen, Jiaxin</creatorcontrib><creatorcontrib>Tian, Shuo</creatorcontrib><creatorcontrib>Xue, Zhiqiang</creatorcontrib><title>High expression of SLC2A1 inhibits ferroptosis and promotes proliferation and invasion of lung adenocarcinoma cells</title><title>Nan fang yi ke da xue xue bao = Journal of Southern Medical University</title><addtitle>Nan Fang Yi Ke Da Xue Xue Bao</addtitle><description>To examine how the glucose transporter SLC2A1 influences the proliferation and migration of lung adenocarcinoma (LUAD) and explore the underlying molecular mechanisms.
We examined the differential expression of SLC2A1 between normal and LUAD tissues in the TCGA database and its prognostic implications. Immunohistochemistry was used to detect SLC2A1 protein levels in clinical samples of LUAD and adjacent tissues, and the association of SLC2A1 expression levels with clinicopathological features of the patients was analyzed. In PC9 cells with stable SLC2A1 overexpression or knockdown, the effects of SLC2A1 expression level on cell proliferation and migration were assessed using CCK-8 and Transwell assays, and the changes in expressions of ferroptosis- and autophagy-related proteins were measured; the occurrence of ferroptosis was confirmed using ROS and Fe
fluorescence staining.
SLC2A1 expression was significantly higher in LUAD tumor tissues than in normal lung tissues (
<0.05) and was associated with worse pat</description><subject>Adenocarcinoma of Lung - genetics</subject><subject>Adenocarcinoma of Lung - metabolism</subject><subject>Adenocarcinoma of Lung - pathology</subject><subject>Autophagy</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Ferroptosis - genetics</subject><subject>Glucose Transporter Type 1 - genetics</subject><subject>Glucose Transporter Type 1 - metabolism</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Neoplasm Invasiveness</subject><subject>Prognosis</subject><issn>1673-4254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhH0A0ar0FZAPHLgk-C92fKwqoEiVONB75CR2a5TYwU4QvD2OaDntaubb0WgBuMcoxwQT8viR2xhdjrmgGSMFywkiLHk5Fldg-S8vwDpGW6MCU4EKjm7AgkpBCk7REsSdPZ6g_h6CTpB30Bv4vt-SDYbWnWxtxwiNDsEPo482QuVaOATf-1HHeelsctU4X86WdV_qEtNN7ghVq51vVGis872Cje66eAuujeqiXp_nChyenw7bXbZ_e3ndbvbZkFpmLSuZqRXV1IiyEE2NmcGSyRITLhgreVkymRTOEEJKCtFqQXVtpORcSMTpCjz8xaaan5OOY9XbOBdQTvspVhQzWTCU6ITendGp7nVbDcH2KvxUlz_RX0a2bJM</recordid><startdate>20241220</startdate><enddate>20241220</enddate><creator>Kuang, Hong</creator><creator>Cai, Wenhan</creator><creator>Liu, Yiming</creator><creator>Wen, Jiaxin</creator><creator>Tian, Shuo</creator><creator>Xue, Zhiqiang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20241220</creationdate><title>High expression of SLC2A1 inhibits ferroptosis and promotes proliferation and invasion of lung adenocarcinoma cells</title><author>Kuang, Hong ; Cai, Wenhan ; Liu, Yiming ; Wen, Jiaxin ; Tian, Shuo ; Xue, Zhiqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p560-d484fba3e3f7857cb14f19498126744868849f1964000a977de73ebf996679063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2024</creationdate><topic>Adenocarcinoma of Lung - genetics</topic><topic>Adenocarcinoma of Lung - metabolism</topic><topic>Adenocarcinoma of Lung - pathology</topic><topic>Autophagy</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Ferroptosis - genetics</topic><topic>Glucose Transporter Type 1 - genetics</topic><topic>Glucose Transporter Type 1 - metabolism</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Neoplasm Invasiveness</topic><topic>Prognosis</topic><toplevel>online_resources</toplevel><creatorcontrib>Kuang, Hong</creatorcontrib><creatorcontrib>Cai, Wenhan</creatorcontrib><creatorcontrib>Liu, Yiming</creatorcontrib><creatorcontrib>Wen, Jiaxin</creatorcontrib><creatorcontrib>Tian, Shuo</creatorcontrib><creatorcontrib>Xue, Zhiqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nan fang yi ke da xue xue bao = Journal of Southern Medical University</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuang, Hong</au><au>Cai, Wenhan</au><au>Liu, Yiming</au><au>Wen, Jiaxin</au><au>Tian, Shuo</au><au>Xue, Zhiqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High expression of SLC2A1 inhibits ferroptosis and promotes proliferation and invasion of lung adenocarcinoma cells</atitle><jtitle>Nan fang yi ke da xue xue bao = Journal of Southern Medical University</jtitle><addtitle>Nan Fang Yi Ke Da Xue Xue Bao</addtitle><date>2024-12-20</date><risdate>2024</risdate><volume>44</volume><issue>12</issue><spage>2404</spage><pages>2404-</pages><issn>1673-4254</issn><abstract>To examine how the glucose transporter SLC2A1 influences the proliferation and migration of lung adenocarcinoma (LUAD) and explore the underlying molecular mechanisms.
We examined the differential expression of SLC2A1 between normal and LUAD tissues in the TCGA database and its prognostic implications. Immunohistochemistry was used to detect SLC2A1 protein levels in clinical samples of LUAD and adjacent tissues, and the association of SLC2A1 expression levels with clinicopathological features of the patients was analyzed. In PC9 cells with stable SLC2A1 overexpression or knockdown, the effects of SLC2A1 expression level on cell proliferation and migration were assessed using CCK-8 and Transwell assays, and the changes in expressions of ferroptosis- and autophagy-related proteins were measured; the occurrence of ferroptosis was confirmed using ROS and Fe
fluorescence staining.
SLC2A1 expression was significantly higher in LUAD tumor tissues than in normal lung tissues (
<0.05) and was associated with worse pat</abstract><cop>China</cop><pmid>39725630</pmid><doi>10.12122/j.issn.1673-4254.2024.12.17</doi></addata></record> |
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| ispartof | Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024-12, Vol.44 (12), p.2404 |
| issn | 1673-4254 |
| language | chi |
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| source | MEDLINE; PubMed Central |
| subjects | Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Autophagy Cell Line, Tumor Cell Movement Cell Proliferation Female Ferroptosis - genetics Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Neoplasm Invasiveness Prognosis |
| title | High expression of SLC2A1 inhibits ferroptosis and promotes proliferation and invasion of lung adenocarcinoma cells |
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