Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis
In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2024-12, Vol.72 (12), p.1110-1115, Article c24-00574 |
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| creator | Do, Hai Nhat Huang, Chih-Yin Chien, Su-Ying Zheng, Li-Guo Chen, You-Ying Zeng, Yun-Ting Su, Jui-Hsin Wen, Zhi-Hong Chang, Yu-Chia Sung, Ping-Jyun |
| description | In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G (2), fragilide P (3), junceellolide D (4), junceellonoid A (5), and juncin ZI (6). The structures of compounds 2-6 were investigated through single-crystal X-ray diffraction analysis, whereas that of 1 was examined through two-dimensional nuclear magnetic resonance analysis. Compounds 1-6 proved active in enhancing the growth of MG-63 human mesenchymal stem cells. |
| doi_str_mv | 10.1248/cpb.c24-00574 |
| format | Article |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anthozoa - chemistry Cell Proliferation - drug effects Crystallography, X-Ray Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Humans Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Molecular Conformation Molecular Structure |
| title | Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral Junceella fragilis |
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