Clinical profile and recovery pattern of dysphonia following inhalation injury: A 10-year review
Inhalation injury may be associated with increased risk of dysphonia and laryngotracheal pathology; however, presentation and recovery patterns are not well documented. To examine the prevalence, clinical characteristics, and recovery patterns of dysphonia and laryngeal pathology following inhalatio...
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| Veröffentlicht in: | Burns 2025-03, Vol.51 (2), p.107321, Article 107321 |
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| creator | Clayton, NA Hall, J Ward, EC Kol, MR Maitz, PK |
| description | Inhalation injury may be associated with increased risk of dysphonia and laryngotracheal pathology; however, presentation and recovery patterns are not well documented.
To examine the prevalence, clinical characteristics, and recovery patterns of dysphonia and laryngeal pathology following inhalation injury.
A retrospective audit was conducted of all burn patients with diagnosed inhalation injury admitted to two Australian burn units over ten years. Demographic, burn, and critical care data were collected in addition to voice and laryngeal outcomes.
Inhalation injury was confirmed in 167 patients (75 % male, mean age 45 years, mean TBSA 23 %, 90 % head/neck burns, 11 % tracheostomy, mean intubation 7 days, mean ICU length of stay [LOS] 11 days, total LOS 39 days). Laryngeal pathology included oedema/erythema, laryngeal granulation, vocal cord palsy/paresis, and laryngeal contracture. Dysphonia was observed in 55%, increasing to 87 % in those with severe inhalation injury (n = 62). By 6 months, dysphonia had resolved in 98 % of the non-severe and 73 % of the severe cohort. Severe inhalation injury was associated with dysphonia (p |
| doi_str_mv | 10.1016/j.burns.2024.107321 |
| format | Article |
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To examine the prevalence, clinical characteristics, and recovery patterns of dysphonia and laryngeal pathology following inhalation injury.
A retrospective audit was conducted of all burn patients with diagnosed inhalation injury admitted to two Australian burn units over ten years. Demographic, burn, and critical care data were collected in addition to voice and laryngeal outcomes.
Inhalation injury was confirmed in 167 patients (75 % male, mean age 45 years, mean TBSA 23 %, 90 % head/neck burns, 11 % tracheostomy, mean intubation 7 days, mean ICU length of stay [LOS] 11 days, total LOS 39 days). Laryngeal pathology included oedema/erythema, laryngeal granulation, vocal cord palsy/paresis, and laryngeal contracture. Dysphonia was observed in 55%, increasing to 87 % in those with severe inhalation injury (n = 62). By 6 months, dysphonia had resolved in 98 % of the non-severe and 73 % of the severe cohort. Severe inhalation injury was associated with dysphonia (p < 0.001), poor dysphonia resolution at six months (p < 0.001), and duration of intubation (p = 0.033).
Dysphonia occurs in one of every two burn patients with inhalation injury, and a quarter of patients with severe injury will still have persistent dysphonia at six months.
•Dysphonia occurs in one of every two patients with inhalation burn injury.•Those with severe inhalation injury are most at risk for dysphonia.•Those with severe inhalation injury have poorer voice outcomes at six months.</description><identifier>ISSN: 0305-4179</identifier><identifier>ISSN: 1879-1409</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/j.burns.2024.107321</identifier><identifier>PMID: 39721235</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Australia - epidemiology ; Burn ; Burns, Inhalation - complications ; Burns, Inhalation - epidemiology ; Burns, Inhalation - therapy ; Contracture - epidemiology ; Contracture - etiology ; Contracture - physiopathology ; Dysphonia ; Dysphonia - epidemiology ; Dysphonia - etiology ; Female ; Humans ; Inhalation ; Intubation, Intratracheal - statistics & numerical data ; Laryngeal Edema - epidemiology ; Laryngeal Edema - etiology ; Laryngeal pathology ; Larynx - injuries ; Length of Stay - statistics & numerical data ; Male ; Middle Aged ; Prevalence ; Recovery of Function ; Retrospective Studies ; Tracheostomy - statistics & numerical data ; Vocal Cord Paralysis - epidemiology ; Vocal Cord Paralysis - etiology ; Voice ; Young Adult</subject><ispartof>Burns, 2025-03, Vol.51 (2), p.107321, Article 107321</ispartof><rights>2024</rights><rights>Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-c90acb8ae4ae3c9db858f978f863e0fb6d75fbb58e09d1f80d513376ebb2bc323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0305417924003619$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39721235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clayton, NA</creatorcontrib><creatorcontrib>Hall, J</creatorcontrib><creatorcontrib>Ward, EC</creatorcontrib><creatorcontrib>Kol, MR</creatorcontrib><creatorcontrib>Maitz, PK</creatorcontrib><title>Clinical profile and recovery pattern of dysphonia following inhalation injury: A 10-year review</title><title>Burns</title><addtitle>Burns</addtitle><description>Inhalation injury may be associated with increased risk of dysphonia and laryngotracheal pathology; however, presentation and recovery patterns are not well documented.
To examine the prevalence, clinical characteristics, and recovery patterns of dysphonia and laryngeal pathology following inhalation injury.
A retrospective audit was conducted of all burn patients with diagnosed inhalation injury admitted to two Australian burn units over ten years. Demographic, burn, and critical care data were collected in addition to voice and laryngeal outcomes.
Inhalation injury was confirmed in 167 patients (75 % male, mean age 45 years, mean TBSA 23 %, 90 % head/neck burns, 11 % tracheostomy, mean intubation 7 days, mean ICU length of stay [LOS] 11 days, total LOS 39 days). Laryngeal pathology included oedema/erythema, laryngeal granulation, vocal cord palsy/paresis, and laryngeal contracture. Dysphonia was observed in 55%, increasing to 87 % in those with severe inhalation injury (n = 62). By 6 months, dysphonia had resolved in 98 % of the non-severe and 73 % of the severe cohort. Severe inhalation injury was associated with dysphonia (p < 0.001), poor dysphonia resolution at six months (p < 0.001), and duration of intubation (p = 0.033).
Dysphonia occurs in one of every two burn patients with inhalation injury, and a quarter of patients with severe injury will still have persistent dysphonia at six months.
•Dysphonia occurs in one of every two patients with inhalation burn injury.•Those with severe inhalation injury are most at risk for dysphonia.•Those with severe inhalation injury have poorer voice outcomes at six months.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Australia - epidemiology</subject><subject>Burn</subject><subject>Burns, Inhalation - complications</subject><subject>Burns, Inhalation - epidemiology</subject><subject>Burns, Inhalation - therapy</subject><subject>Contracture - epidemiology</subject><subject>Contracture - etiology</subject><subject>Contracture - physiopathology</subject><subject>Dysphonia</subject><subject>Dysphonia - epidemiology</subject><subject>Dysphonia - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhalation</subject><subject>Intubation, Intratracheal - statistics & numerical data</subject><subject>Laryngeal Edema - epidemiology</subject><subject>Laryngeal Edema - etiology</subject><subject>Laryngeal pathology</subject><subject>Larynx - injuries</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Recovery of Function</subject><subject>Retrospective Studies</subject><subject>Tracheostomy - statistics & numerical data</subject><subject>Vocal Cord Paralysis - epidemiology</subject><subject>Vocal Cord Paralysis - etiology</subject><subject>Voice</subject><subject>Young Adult</subject><issn>0305-4179</issn><issn>1879-1409</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhq2qqITQX1Cp8rGXDfZ6N2tX6gFFfElIXOBs_DEujhw7tXdB--8xhPbYucxo9L4zeh-EvlGyooSuz7YrPeVYVi1pu7oZWEs_oQXlg2hoR8RntCCM9E1HB3GMTkrZklo9J1_QMRNDS1vWL9DjJvjojQp4n5PzAbCKFmcw6RnyjPdqHCFHnBy2c9k_pegVdimE9OLjb-zjkwpq9CnWcTvl-Sc-x5Q0M6hcjzx7eDlFR06FAl8_-hI9XF7cb66b27urm835bWNa3o2NEUQZzRV0CpgRVvOeOzFwx9cMiNNrO_RO654DEZY6TmxPGRvWoHWrDWvZEv043K05_kxQRrnzxUAIKkKaimS0Ez3jtLqWiB2kJqdSMji5z36n8iwpkW9o5Va-o5VvaOUBbXV9_3gw6R3Yf56_LKvg10EANWaNnmUxHqIB6yvPUdrk__vgFU63jKU</recordid><startdate>20250301</startdate><enddate>20250301</enddate><creator>Clayton, NA</creator><creator>Hall, J</creator><creator>Ward, EC</creator><creator>Kol, MR</creator><creator>Maitz, PK</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250301</creationdate><title>Clinical profile and recovery pattern of dysphonia following inhalation injury: A 10-year review</title><author>Clayton, NA ; Hall, J ; Ward, EC ; Kol, MR ; Maitz, PK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-c90acb8ae4ae3c9db858f978f863e0fb6d75fbb58e09d1f80d513376ebb2bc323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Australia - epidemiology</topic><topic>Burn</topic><topic>Burns, Inhalation - complications</topic><topic>Burns, Inhalation - epidemiology</topic><topic>Burns, Inhalation - therapy</topic><topic>Contracture - epidemiology</topic><topic>Contracture - etiology</topic><topic>Contracture - physiopathology</topic><topic>Dysphonia</topic><topic>Dysphonia - epidemiology</topic><topic>Dysphonia - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhalation</topic><topic>Intubation, Intratracheal - statistics & numerical data</topic><topic>Laryngeal Edema - epidemiology</topic><topic>Laryngeal Edema - etiology</topic><topic>Laryngeal pathology</topic><topic>Larynx - injuries</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Recovery of Function</topic><topic>Retrospective Studies</topic><topic>Tracheostomy - statistics & numerical data</topic><topic>Vocal Cord Paralysis - epidemiology</topic><topic>Vocal Cord Paralysis - etiology</topic><topic>Voice</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clayton, NA</creatorcontrib><creatorcontrib>Hall, J</creatorcontrib><creatorcontrib>Ward, EC</creatorcontrib><creatorcontrib>Kol, MR</creatorcontrib><creatorcontrib>Maitz, PK</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clayton, NA</au><au>Hall, J</au><au>Ward, EC</au><au>Kol, MR</au><au>Maitz, PK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical profile and recovery pattern of dysphonia following inhalation injury: A 10-year review</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2025-03-01</date><risdate>2025</risdate><volume>51</volume><issue>2</issue><spage>107321</spage><pages>107321-</pages><artnum>107321</artnum><issn>0305-4179</issn><issn>1879-1409</issn><eissn>1879-1409</eissn><abstract>Inhalation injury may be associated with increased risk of dysphonia and laryngotracheal pathology; however, presentation and recovery patterns are not well documented.
To examine the prevalence, clinical characteristics, and recovery patterns of dysphonia and laryngeal pathology following inhalation injury.
A retrospective audit was conducted of all burn patients with diagnosed inhalation injury admitted to two Australian burn units over ten years. Demographic, burn, and critical care data were collected in addition to voice and laryngeal outcomes.
Inhalation injury was confirmed in 167 patients (75 % male, mean age 45 years, mean TBSA 23 %, 90 % head/neck burns, 11 % tracheostomy, mean intubation 7 days, mean ICU length of stay [LOS] 11 days, total LOS 39 days). Laryngeal pathology included oedema/erythema, laryngeal granulation, vocal cord palsy/paresis, and laryngeal contracture. Dysphonia was observed in 55%, increasing to 87 % in those with severe inhalation injury (n = 62). By 6 months, dysphonia had resolved in 98 % of the non-severe and 73 % of the severe cohort. Severe inhalation injury was associated with dysphonia (p < 0.001), poor dysphonia resolution at six months (p < 0.001), and duration of intubation (p = 0.033).
Dysphonia occurs in one of every two burn patients with inhalation injury, and a quarter of patients with severe injury will still have persistent dysphonia at six months.
•Dysphonia occurs in one of every two patients with inhalation burn injury.•Those with severe inhalation injury are most at risk for dysphonia.•Those with severe inhalation injury have poorer voice outcomes at six months.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>39721235</pmid><doi>10.1016/j.burns.2024.107321</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Australia - epidemiology Burn Burns, Inhalation - complications Burns, Inhalation - epidemiology Burns, Inhalation - therapy Contracture - epidemiology Contracture - etiology Contracture - physiopathology Dysphonia Dysphonia - epidemiology Dysphonia - etiology Female Humans Inhalation Intubation, Intratracheal - statistics & numerical data Laryngeal Edema - epidemiology Laryngeal Edema - etiology Laryngeal pathology Larynx - injuries Length of Stay - statistics & numerical data Male Middle Aged Prevalence Recovery of Function Retrospective Studies Tracheostomy - statistics & numerical data Vocal Cord Paralysis - epidemiology Vocal Cord Paralysis - etiology Voice Young Adult |
| title | Clinical profile and recovery pattern of dysphonia following inhalation injury: A 10-year review |
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