Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

Sodium dehydroacetate (DHA-Na), a widely used preservative, can induce sex-differentiated coagulation disorders primarily resulting from its metabolism. However, the underlying mechanisms remain poorly understood. Here, we identified several Cytochrome P450 (CYP450) sub-enzymes involved in sex diffe...

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Veröffentlicht in:	NPJ science of food 2024-12, Vol.8 (1), p.110-12, Article 110
Hauptverfasser:	Zhang, Meng, Du, Pengfei, Xiao, Yirong, Liu, Hao, Wang, Meixue, Zhang, Yumei, Chen, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/45/607 692/499 Chemistry Chemistry and Materials Science Chemistry/Food Science Coagulation CYP1A2 protein Cytochrome P450 Cytochromes P450 Enzymes Females Food Microbiology Food Science Gender differences Isoforms Males Metabolism Metabolites Nutrition Preservatives Sex differences Sodium
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