Ischemic Stroke Prevention in Patients Atrial Fibrillation and a Recent Ischemic Stroke, TIA, or Intracranial Hemorrhage; a World Stroke Organisation (WSO) Scientific Statement
Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current eviden...
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| Veröffentlicht in: | International journal of stroke 2024-12, p.17474930241312649 |
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| creator | Sposato, Luciano A Cameron, Alan Johansen, Michelle C Katan, Mira Murthy, Santosh Bhaskar Schachter, Micaela Sur, Nicole Yaghi, Shadi Aspberg, Sara Caso, Valeria Hsieh, Cheng-Yang Hilz, Max Nucera, Antonia Seiffge, David J Sheppard, Mary Martins, Sheila Ouriques Bahit, M Cecilia Scheitz, Jan F Shoamanesh, Ashkan |
| description | Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current evidence this topic, highlights areas of current controversy, identifies knowledge gaps, and proposes priorities for future research.
We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions. Based on the strength of available evidence and knowledge gaps, we identify topics that need to be prioritized in future research. For this purpose, we adopt a novel classification of evidence strength based on the availability of publications in which the primary population is patients with recent ( |
| doi_str_mv | 10.1177/17474930241312649 |
| format | Article |
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We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions. Based on the strength of available evidence and knowledge gaps, we identify topics that need to be prioritized in future research. For this purpose, we adopt a novel classification of evidence strength based on the availability of publications in which the primary population is patients with recent (<6 months) cerebrovascular events, whether the primary study endpoint is a recurrent ischemic stroke, and the quality of the studies (e.g., observational vs. randomized controlled trial).
Priority areas include AF screening, molecular biomarkers, AF subtype classification, anticoagulation in device-detected AF, timing of anticoagulation initiation, effective management of breakthrough strokes on existing anticoagulant therapy, the role of left atrial appendage closure, novel approaches, and antithrombotic therapy post-intracranial hemorrhage. Strength of currently available evidence varies across the selected topics, with early anticoagulation being the one showing more consistent data.
Several knowledge gaps persist in most areas related to secondary stroke prevention in AF. Prioritizing research in this field is crucial to advance current knowledge and improve clinical care.</description><identifier>ISSN: 1747-4930</identifier><identifier>ISSN: 1747-4949</identifier><identifier>EISSN: 1747-4949</identifier><identifier>DOI: 10.1177/17474930241312649</identifier><identifier>PMID: 39719823</identifier><language>eng</language><publisher>United States</publisher><ispartof>International journal of stroke, 2024-12, p.17474930241312649</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8452-712X ; 0000-0002-2020-8891 ; 0000-0001-6425-9343 ; 0000-0001-6965-1109 ; 0000-0003-3890-3849 ; 0000-0002-2802-1626 ; 0000-0002-8772-4073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39719823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sposato, Luciano A</creatorcontrib><creatorcontrib>Cameron, Alan</creatorcontrib><creatorcontrib>Johansen, Michelle C</creatorcontrib><creatorcontrib>Katan, Mira</creatorcontrib><creatorcontrib>Murthy, Santosh Bhaskar</creatorcontrib><creatorcontrib>Schachter, Micaela</creatorcontrib><creatorcontrib>Sur, Nicole</creatorcontrib><creatorcontrib>Yaghi, Shadi</creatorcontrib><creatorcontrib>Aspberg, Sara</creatorcontrib><creatorcontrib>Caso, Valeria</creatorcontrib><creatorcontrib>Hsieh, Cheng-Yang</creatorcontrib><creatorcontrib>Hilz, Max</creatorcontrib><creatorcontrib>Nucera, Antonia</creatorcontrib><creatorcontrib>Seiffge, David J</creatorcontrib><creatorcontrib>Sheppard, Mary</creatorcontrib><creatorcontrib>Martins, Sheila Ouriques</creatorcontrib><creatorcontrib>Bahit, M Cecilia</creatorcontrib><creatorcontrib>Scheitz, Jan F</creatorcontrib><creatorcontrib>Shoamanesh, Ashkan</creatorcontrib><title>Ischemic Stroke Prevention in Patients Atrial Fibrillation and a Recent Ischemic Stroke, TIA, or Intracranial Hemorrhage; a World Stroke Organisation (WSO) Scientific Statement</title><title>International journal of stroke</title><addtitle>Int J Stroke</addtitle><description>Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current evidence this topic, highlights areas of current controversy, identifies knowledge gaps, and proposes priorities for future research.
We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions. Based on the strength of available evidence and knowledge gaps, we identify topics that need to be prioritized in future research. For this purpose, we adopt a novel classification of evidence strength based on the availability of publications in which the primary population is patients with recent (<6 months) cerebrovascular events, whether the primary study endpoint is a recurrent ischemic stroke, and the quality of the studies (e.g., observational vs. randomized controlled trial).
Priority areas include AF screening, molecular biomarkers, AF subtype classification, anticoagulation in device-detected AF, timing of anticoagulation initiation, effective management of breakthrough strokes on existing anticoagulant therapy, the role of left atrial appendage closure, novel approaches, and antithrombotic therapy post-intracranial hemorrhage. Strength of currently available evidence varies across the selected topics, with early anticoagulation being the one showing more consistent data.
Several knowledge gaps persist in most areas related to secondary stroke prevention in AF. 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a World Stroke Organisation (WSO) Scientific Statement</atitle><jtitle>International journal of stroke</jtitle><addtitle>Int J Stroke</addtitle><date>2024-12-24</date><risdate>2024</risdate><spage>17474930241312649</spage><pages>17474930241312649-</pages><issn>1747-4930</issn><issn>1747-4949</issn><eissn>1747-4949</eissn><abstract>Secondary stroke prevention in patients with atrial fibrillation (AF) is one of the fastest growing areas in the field of cerebrovascular diseases. This Scientific statement from the World Stroke Organization Brain & Heart Task Force provides a critical analysis of the strength of current evidence this topic, highlights areas of current controversy, identifies knowledge gaps, and proposes priorities for future research.
We select topics with the highest clinical relevance and perform a systematic search to answer specific practical questions. Based on the strength of available evidence and knowledge gaps, we identify topics that need to be prioritized in future research. For this purpose, we adopt a novel classification of evidence strength based on the availability of publications in which the primary population is patients with recent (<6 months) cerebrovascular events, whether the primary study endpoint is a recurrent ischemic stroke, and the quality of the studies (e.g., observational vs. randomized controlled trial).
Priority areas include AF screening, molecular biomarkers, AF subtype classification, anticoagulation in device-detected AF, timing of anticoagulation initiation, effective management of breakthrough strokes on existing anticoagulant therapy, the role of left atrial appendage closure, novel approaches, and antithrombotic therapy post-intracranial hemorrhage. Strength of currently available evidence varies across the selected topics, with early anticoagulation being the one showing more consistent data.
Several knowledge gaps persist in most areas related to secondary stroke prevention in AF. Prioritizing research in this field is crucial to advance current knowledge and improve clinical care.</abstract><cop>United States</cop><pmid>39719823</pmid><doi>10.1177/17474930241312649</doi><orcidid>https://orcid.org/0000-0002-8452-712X</orcidid><orcidid>https://orcid.org/0000-0002-2020-8891</orcidid><orcidid>https://orcid.org/0000-0001-6425-9343</orcidid><orcidid>https://orcid.org/0000-0001-6965-1109</orcidid><orcidid>https://orcid.org/0000-0003-3890-3849</orcidid><orcidid>https://orcid.org/0000-0002-2802-1626</orcidid><orcidid>https://orcid.org/0000-0002-8772-4073</orcidid></addata></record> |
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| title | Ischemic Stroke Prevention in Patients Atrial Fibrillation and a Recent Ischemic Stroke, TIA, or Intracranial Hemorrhage; a World Stroke Organisation (WSO) Scientific Statement |
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