Effects of ALS-associated 5’tiRNAGly-GCC on the transcriptomic and proteomic profile of primary neurons in vitro

tRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene are...

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Veröffentlicht in:	Experimental neurology 2025-03, Vol.385, p.115128, Article 115128
Hauptverfasser:	Jirström, Elisabeth, Matveeva, Anna, Baindoor, Sharada, Donovan, Paul, Ma, Qilian, Morrissey, Elena Perez, Arijs, Ingrid, Boeckx, Bram, Lambrechts, Diether, Garcia-Munoz, Amaya, Dillon, Eugène T., Wynne, Kieran, Ying, Zheng, Matallanas, David, Hogg, Marion C., Prehn, Jochen H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis (ALS) Angiogenin (ANG) Small non-coding RNA (sncRNA) Stress response Transfer RNA-derived stress-induced RNA (tiRNAs)
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