The effects of fasting and dehydration on pupillary light reflex as detected by pupillometry
The pupillary light reflex could serve as a valuable method for measuring dynamic responses in the autonomic nervous system (ANS). However, it remains unclear whether physiological conditions such as fasting and dehydration affect pupillary reflexes. In this study, we investigated the effects of fas...
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| Veröffentlicht in: | Clinical physiology and functional imaging 2025-01, Vol.45 (1), p.e12921 |
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| creator | Adam, Mehmet Gündoğan, Ali Osman Tezcan, Ali Oltulu, Refik Belviranlı, Selman Mirza, Enver Okka, Mehmet |
| description | The pupillary light reflex could serve as a valuable method for measuring dynamic responses in the autonomic nervous system (ANS). However, it remains unclear whether physiological conditions such as fasting and dehydration affect pupillary reflexes. In this study, we investigated the effects of fasting and dehydration on pupillary responses using pupillometry. Measurements were taken after at least 12 h of Ramadan fasting (RF) and under a normal dietary pattern (NDP). Forty-nine volunteers, who had no complaints related to the ANS, participated in the study. The initial pupil diameter (IPD), amplitude of contraction, contraction velocity, contraction latency, dilatation duration, and dilation velocity were recorded. The IPD was 5.91 ± 0.65 mm in the RF condition and 5.72 ± 0.65 mm in the NDP condition (p |
| doi_str_mv | 10.1111/cpf.12921 |
| format | Article |
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However, it remains unclear whether physiological conditions such as fasting and dehydration affect pupillary reflexes. In this study, we investigated the effects of fasting and dehydration on pupillary responses using pupillometry. Measurements were taken after at least 12 h of Ramadan fasting (RF) and under a normal dietary pattern (NDP). Forty-nine volunteers, who had no complaints related to the ANS, participated in the study. The initial pupil diameter (IPD), amplitude of contraction, contraction velocity, contraction latency, dilatation duration, and dilation velocity were recorded. The IPD was 5.91 ± 0.65 mm in the RF condition and 5.72 ± 0.65 mm in the NDP condition (p < 0.001). Both contraction amplitude (CA) and dilatation velocity (DV) were higher in the RF condition (p = 0.010 and p = 0.022, respectively). Females exhibited a greater IPD in the NDP condition (p = 0.023). Differences between genders in the RF condition were observed in CA (p = 0.002), dilation duration (p = 0.016) and dilation latency (p = 0.041). These findings indicate that fasting and dehydration influence IPD, CA and DV. Therefore, it is informative to consider fasting and dehydration status when evaluating pupillometry results.</description><identifier>ISSN: 1475-097X</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12921</identifier><identifier>PMID: 39716380</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Autonomic Nervous System - physiology ; Dehydration - physiopathology ; Fasting - physiology ; Female ; Humans ; Islam ; Light ; Male ; Organism Hydration Status ; Predictive Value of Tests ; Pupil - physiology ; Reaction Time ; Reflex, Pupillary - physiology ; Sex Factors ; Time Factors ; Young Adult</subject><ispartof>Clinical physiology and functional imaging, 2025-01, Vol.45 (1), p.e12921</ispartof><rights>2024 Scandinavian Society of Clinical Physiology and Nuclear Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7305-3443 ; 0000-0003-0552-5212 ; 0000-0003-0272-7345 ; 0000-0002-9686-0181 ; 0000-0003-2447-6524 ; 0000-0002-8847-5726</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39716380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adam, Mehmet</creatorcontrib><creatorcontrib>Gündoğan, Ali Osman</creatorcontrib><creatorcontrib>Tezcan, Ali</creatorcontrib><creatorcontrib>Oltulu, Refik</creatorcontrib><creatorcontrib>Belviranlı, Selman</creatorcontrib><creatorcontrib>Mirza, Enver</creatorcontrib><creatorcontrib>Okka, Mehmet</creatorcontrib><title>The effects of fasting and dehydration on pupillary light reflex as detected by pupillometry</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>The pupillary light reflex could serve as a valuable method for measuring dynamic responses in the autonomic nervous system (ANS). However, it remains unclear whether physiological conditions such as fasting and dehydration affect pupillary reflexes. In this study, we investigated the effects of fasting and dehydration on pupillary responses using pupillometry. Measurements were taken after at least 12 h of Ramadan fasting (RF) and under a normal dietary pattern (NDP). Forty-nine volunteers, who had no complaints related to the ANS, participated in the study. The initial pupil diameter (IPD), amplitude of contraction, contraction velocity, contraction latency, dilatation duration, and dilation velocity were recorded. The IPD was 5.91 ± 0.65 mm in the RF condition and 5.72 ± 0.65 mm in the NDP condition (p < 0.001). Both contraction amplitude (CA) and dilatation velocity (DV) were higher in the RF condition (p = 0.010 and p = 0.022, respectively). Females exhibited a greater IPD in the NDP condition (p = 0.023). Differences between genders in the RF condition were observed in CA (p = 0.002), dilation duration (p = 0.016) and dilation latency (p = 0.041). These findings indicate that fasting and dehydration influence IPD, CA and DV. Therefore, it is informative to consider fasting and dehydration status when evaluating pupillometry results.</description><subject>Adult</subject><subject>Autonomic Nervous System - physiology</subject><subject>Dehydration - physiopathology</subject><subject>Fasting - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Islam</subject><subject>Light</subject><subject>Male</subject><subject>Organism Hydration Status</subject><subject>Predictive Value of Tests</subject><subject>Pupil - physiology</subject><subject>Reaction Time</subject><subject>Reflex, Pupillary - physiology</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1475-097X</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1LAzEQhoMotlYP_gHJ0cvWfOwmm6MUq0LBSw8ehCVf067sl5ssuP_egBUcXpg5PPPyziB0S8mapnqwA6wpU4yeoSXNZZERJd_P_80LdBXCJyFU8lxeogVXkgpekiX62B899gDexoB7wKBDrLsD1p3Dzh9nN-pY9x1OGqahbho9zripD8eIRw-N_8Y6JDCmfe-wmU9U3_o4ztfoAnQT_M2pr9B--7TfvGS7t-fXzeMuGwpBMlbYQgtuAGRuiZCOOMVsaTklkkPhDAivrVbKWlClNgaYM5Y56agQAJqv0P2v7TD2X5MPsWrrYH3K2vl-ChWneVnmLPkl9O6ETqb1rhrGuk0XVX8P4T-qqmQY</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Adam, Mehmet</creator><creator>Gündoğan, Ali Osman</creator><creator>Tezcan, Ali</creator><creator>Oltulu, Refik</creator><creator>Belviranlı, Selman</creator><creator>Mirza, Enver</creator><creator>Okka, Mehmet</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7305-3443</orcidid><orcidid>https://orcid.org/0000-0003-0552-5212</orcidid><orcidid>https://orcid.org/0000-0003-0272-7345</orcidid><orcidid>https://orcid.org/0000-0002-9686-0181</orcidid><orcidid>https://orcid.org/0000-0003-2447-6524</orcidid><orcidid>https://orcid.org/0000-0002-8847-5726</orcidid></search><sort><creationdate>202501</creationdate><title>The effects of fasting and dehydration on pupillary light reflex as detected by pupillometry</title><author>Adam, Mehmet ; Gündoğan, Ali Osman ; Tezcan, Ali ; Oltulu, Refik ; Belviranlı, Selman ; Mirza, Enver ; Okka, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p560-25c5a63bff74c067d0d92c8c31073f5dbf6eaca99ccf98abbf2dbc2d7d166ffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Autonomic Nervous System - physiology</topic><topic>Dehydration - physiopathology</topic><topic>Fasting - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Islam</topic><topic>Light</topic><topic>Male</topic><topic>Organism Hydration Status</topic><topic>Predictive Value of Tests</topic><topic>Pupil - physiology</topic><topic>Reaction Time</topic><topic>Reflex, Pupillary - physiology</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adam, Mehmet</creatorcontrib><creatorcontrib>Gündoğan, Ali Osman</creatorcontrib><creatorcontrib>Tezcan, Ali</creatorcontrib><creatorcontrib>Oltulu, Refik</creatorcontrib><creatorcontrib>Belviranlı, Selman</creatorcontrib><creatorcontrib>Mirza, Enver</creatorcontrib><creatorcontrib>Okka, Mehmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adam, Mehmet</au><au>Gündoğan, Ali Osman</au><au>Tezcan, Ali</au><au>Oltulu, Refik</au><au>Belviranlı, Selman</au><au>Mirza, Enver</au><au>Okka, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of fasting and dehydration on pupillary light reflex as detected by pupillometry</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2025-01</date><risdate>2025</risdate><volume>45</volume><issue>1</issue><spage>e12921</spage><pages>e12921-</pages><issn>1475-097X</issn><eissn>1475-097X</eissn><abstract>The pupillary light reflex could serve as a valuable method for measuring dynamic responses in the autonomic nervous system (ANS). However, it remains unclear whether physiological conditions such as fasting and dehydration affect pupillary reflexes. In this study, we investigated the effects of fasting and dehydration on pupillary responses using pupillometry. Measurements were taken after at least 12 h of Ramadan fasting (RF) and under a normal dietary pattern (NDP). Forty-nine volunteers, who had no complaints related to the ANS, participated in the study. The initial pupil diameter (IPD), amplitude of contraction, contraction velocity, contraction latency, dilatation duration, and dilation velocity were recorded. The IPD was 5.91 ± 0.65 mm in the RF condition and 5.72 ± 0.65 mm in the NDP condition (p < 0.001). Both contraction amplitude (CA) and dilatation velocity (DV) were higher in the RF condition (p = 0.010 and p = 0.022, respectively). Females exhibited a greater IPD in the NDP condition (p = 0.023). Differences between genders in the RF condition were observed in CA (p = 0.002), dilation duration (p = 0.016) and dilation latency (p = 0.041). These findings indicate that fasting and dehydration influence IPD, CA and DV. Therefore, it is informative to consider fasting and dehydration status when evaluating pupillometry results.</abstract><cop>England</cop><pmid>39716380</pmid><doi>10.1111/cpf.12921</doi><orcidid>https://orcid.org/0000-0001-7305-3443</orcidid><orcidid>https://orcid.org/0000-0003-0552-5212</orcidid><orcidid>https://orcid.org/0000-0003-0272-7345</orcidid><orcidid>https://orcid.org/0000-0002-9686-0181</orcidid><orcidid>https://orcid.org/0000-0003-2447-6524</orcidid><orcidid>https://orcid.org/0000-0002-8847-5726</orcidid></addata></record> |
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| subjects | Adult Autonomic Nervous System - physiology Dehydration - physiopathology Fasting - physiology Female Humans Islam Light Male Organism Hydration Status Predictive Value of Tests Pupil - physiology Reaction Time Reflex, Pupillary - physiology Sex Factors Time Factors Young Adult |
| title | The effects of fasting and dehydration on pupillary light reflex as detected by pupillometry |
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