The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity

Propiconazole is a triazole fungicide previously shown to induce triglyceride accumulation in human liver HepaRG cells, potentially via activation of the Pregnane X Receptor (PXR). However, whether propiconazole can disrupt hepatic and whole-body metabolism in vivo is currently unknown. Therefore, w...

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Veröffentlicht in:	Archives of toxicology 2024-12
Hauptverfasser:	Attema, Brecht, Kummu, Outi, Krutáková, Mária, Pavek, Petr, Hakkola, Jukka, Hooiveld, Guido J E J, Kersten, Sander
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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