Aluminum-catalyzed anti-Markovnikov hydroamination of aromatic alkenes with aromatic amines
Herein, we report a novel Al compound supported by a NacNac ligand that facilitates the anti-Markovnikov hydroamination of aromatic alkenes and primary amines. This represents the first instance of an aluminum-catalyzed intermolecular hydroamination of alkenes, successfully synthesizing a variety of...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-12 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Yan, Wenliang Ma, Xiaoli Li, Qifeng Pang, Ziyuan Yang, Xiaobo Chen, Yiwen Yang, Zhi |
| description | Herein, we report a novel Al compound supported by a NacNac ligand that facilitates the anti-Markovnikov hydroamination of aromatic alkenes and primary amines. This represents the first instance of an aluminum-catalyzed intermolecular hydroamination of alkenes, successfully synthesizing a variety of aromatic imine derivatives. The proposed mechanism suggests that the coordination activation of
BuOK by ether solvents is crucial, allowing the
BuO
anion to coordinate with the catalyst's Al center, thus forming a key intermediate. |
| doi_str_mv | 10.1039/d4ob01820f |
| format | Article |
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BuOK by ether solvents is crucial, allowing the
BuO
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BuOK by ether solvents is crucial, allowing the
BuO
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BuOK by ether solvents is crucial, allowing the
BuO
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Aluminum-catalyzed anti-Markovnikov hydroamination of aromatic alkenes with aromatic amines |
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