Fc-FcγRI Complexes: Molecular Dynamics Simulations Shed Light on Ectodomain D3's Potential Role in IgG Binding

FcγRI plays a crucial role in the effector function of IgG antibodies, interacting with the lower hinge region of IgG1 with nanomolar affinity. Binding occurs specifically in domain 2 (D2) of the FcγRI ectodomain, while domain 3 (D3) is a flexible linker. The D3 domain is positioned away from the Ig...

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Veröffentlicht in:	ACS omega 2024-12, Vol.9 (50), p.49272
Hauptverfasser:	Kutlu, Aslı, Çapkın, Eda, Adacan, Kaan, Yüce, Meral
Format:	Artikel
Sprache:	eng
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